| Autor: |
Bhosale SR; Medicinal Chemistry Research Laboratory, Department of Chemistry, Shivaji University, Kolhapur 416004, India., Bhosale RR; Analytical Chemistry and Material Science Research Laboratory, Department of Chemistry, Shivaji University, Kolhapur 416004, India., Patil DN; Department of Biotechnology, Shivaji University, Kolhapur 416004, India., Dhavale RP; Department of Materials Science and Engineering, Yonsei University, Seoul 03722, South Korea., Kolekar GB; Fluorescence Spectroscopy Research Laboratory, Department of Chemistry, Shivaji University, Kolhapur 416004, India., Shimpale VB; Department of Botany, The new College, Kolhapur 416012, India., Anbhule PV; Medicinal Chemistry Research Laboratory, Department of Chemistry, Shivaji University, Kolhapur 416004, India. |
| Abstrakt: |
Scientists have investigated the possibility of employing nanomaterials as drug carriers. These nanomaterials can preserve their content and transport it to the target region in the body. In this investigation, we proposed a simple method for developing distinctive, bioderived nanostructures with mesoporous carbon nanoparticles impregnated with tungsten oxide (WO 3 ). Prior to characterizing and encapsulating WO 3 with bioderived mesoporous carbon, the anticancer drug doxorubicin (DOX) was added to the nanoparticles and examined loading and release study. The approaches for both nanoparticle production and characterization are discussed in detail. Colloidal qualities of the nanomaterial can be effectively preserved while also allowing transdermal transportation of nanoparticles into the body by forming them into green, reusable, and porous nanostructures. Although the theories of nanoparticles and bioderived carbon each have been studied separately, the combination presents a new route to applications connected to nanomedicine. Furthermore, this sample was used to study exotic biomedical applications, such as antioxidant, antimicrobial, and anticancer activities. The W-3 sample had lower antioxidant activity (44.01%) than the C@W sample (56.34%), which was the most potent. A high DOX entrapment effectiveness of 97% was eventually achieved by the C@W sample, compared to a pure WO 3 entrapment efficiency of 91%. It was observed that the Carbon/WO 3 composite (C@W) sample showed more efficacy because the mesoporous carbon composition with WO 3 increases the average surface area and surface-active locations. |
