abkBA toxin-antitoxin system may act as antipersister modules in Acinetobacter baumannii clinical isolates.
| Autor: | Latifi F; Department of Medical Microbiology, Faculty of Medicine, Ilam University of Medical Science, Ilam, Iran., Hashemi A; Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Kalani BS; Department of Medical Microbiology, Faculty of Medicine, Ilam University of Medical Science, Ilam, Iran., Pakzad I; Department of Medical Microbiology, Faculty of Medicine, Ilam University of Medical Science, Ilam, Iran., Hematian A; Department of Medical Microbiology, Faculty of Medicine, Ilam University of Medical Science, Ilam, Iran. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Future microbiology [Future Microbiol] 2023 Jul; Vol. 18, pp. 707-714. Date of Electronic Publication: 2023 Aug 08. |
| DOI: | 10.2217/fmb-2022-0271 |
| Abstrakt: | Aim: Persistence cells comprise a subpopulation of bacteria that is resistant to treatment. In this study, the role of the toxin-antitoxin (TA) system in the formation of persistence cells of Acinetobacter baumannii isolates was investigated. Methods: After confirming all isolates, TA systems abkBA, mqsRA and higBA were identified. Persister cells were confirmed using the standard method. Real-time PCR was used to compare the expression of TA systems in isolates in persistence and normal states. Results: The abkAB system was present in all isolates; 4% of isolates formed persister cells. The expression level of the abkB gene in persistent isolates showed a sevenfold increase compared with nonpersistent isolates. Conclusion: The abkBA system is proposed as an antipersistence target in A. baumannii isolates. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|