Plant-derived nanomaterials (PDNM): a review on pharmacological potentials against pathogenic microbes, antimicrobial resistance (AMR) and some metabolic diseases.

Autor: Okeke ES; Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, 410001 Enugu Nigeria.; Natural Science Unit, School of General Studies, University of Nigeria, Nsukka, 410001 Enugu Nigeria.; Institute of Environmental Health and Ecological Security, School of Environment and Safety Engineering, Jiangsu University, Zhenjiang, 212013 Jiangsu China., Nweze EJ; Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, 410001 Enugu Nigeria., Anaduaka EG; Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, 410001 Enugu Nigeria.; Department of Genetics and Biotechnology, Faculty of Biological Sciences, University of Nigeria, Nsukka, 410001 Enugu Nigeria., Okoye CO; School of Environment and Safety Engineering, Jiangsu University, Zhenjiang, 212013 People's Republic of China.; Department of Zoology and Environmental Biology, University of Nigeria, Nsukka, 410001 Enugu Nigeria.; Biofuels Institute, Jiangsu University, Zhenjiang, 212013 People's Republic of China., Anosike CA; Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, 410001 Enugu Nigeria., Joshua PE; Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, 410001 Enugu Nigeria.; Department of Genetics and Biotechnology, Faculty of Biological Sciences, University of Nigeria, Nsukka, 410001 Enugu Nigeria., Ezeorba TPC; Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, 410001 Enugu Nigeria.; Department of Genetics and Biotechnology, Faculty of Biological Sciences, University of Nigeria, Nsukka, 410001 Enugu Nigeria.; Department of Environmental Health and Risk Management, College of Life and Environmental Sciences, University of Birmingham Edgbaston, Birmingham, B15 2TT UK.
Jazyk: angličtina
Zdroj: 3 Biotech [3 Biotech] 2023 Sep; Vol. 13 (9), pp. 291. Date of Electronic Publication: 2023 Aug 04.
DOI: 10.1007/s13205-023-03713-w
Abstrakt: Plant-derived nanomaterials (PDNM) have gained significant attention recently due to their potential pharmacological applications against pathogenic microbes, antimicrobial resistance (AMR), and certain metabolic diseases. This review introduces the concept of PDNMs and their unique properties, including their small size, high surface area, and ability to penetrate biological barriers. Besides various methods for synthesizing PDNMs, such as green synthesis techniques that utilize plant extracts and natural compounds, the advantages of using plant-derived materials, such as their biocompatibility, biodegradability, and low toxicity, were elucidated. In addition, it examines the recent and emerging trends in nanomaterials derived from plant approaches to combat antimicrobial resistance and metabolic diseases. The sizes of nanomaterials and their surface areas are vital as they play essential roles in the interactions and relationships between these materials and the biological components or organization. We critically analyze the biomedical applications of nanoparticles which include antibacterial composites for implantable devices and nanosystems to combat antimicrobial resistance, enhance antibiotic delivery, and improve microbial diagnostic/detection systemsIn addition, plant extracts can potentially interfere with metabolic syndrome pathways; hence most nano-formulations can reduce chronic inflammation, insulin resistance, oxidative stress, lipid profile, and antimicrobial resistance. As a result, these innovative plant-based nanosystems may be a promising contender for various pharmacological applications.
Competing Interests: Conflict of interestThere is no existing conflict of interest.
(© The Author(s) 2023.)
Databáze: MEDLINE
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