Lower serum 15-HETE level predicts nasal ILC2 accumulation during COX-1 inhibition in AERD.

Autor: Badrani JH; Section of Allergy and Immunology, Department of Medicine, University of California San Diego, La Jolla, Calif; Veterans Affairs San Diego Healthcare System, La Jolla, Calif., Cavagnero K; Section of Allergy and Immunology, Department of Medicine, University of California San Diego, La Jolla, Calif., Eastman JJ; Section of Allergy and Immunology, Department of Medicine, University of California San Diego, La Jolla, Calif., Kim AS; Section of Allergy and Immunology, Department of Medicine, University of California San Diego, La Jolla, Calif., Strohm A; Section of Allergy and Immunology, Department of Medicine, University of California San Diego, La Jolla, Calif; Veterans Affairs San Diego Healthcare System, La Jolla, Calif., Yan C; Department of Otolaryngology, University of California, San Diego, Calif., Deconde A; Department of Otolaryngology, University of California, San Diego, Calif., Zuraw BL; Section of Allergy and Immunology, Department of Medicine, University of California San Diego, La Jolla, Calif; Veterans Affairs San Diego Healthcare System, La Jolla, Calif., White AA; Divison of Allergy, Asthma and Immunology, Scripps Clinic, La Jolla, Calif., Christiansen SC; Section of Allergy and Immunology, Department of Medicine, University of California San Diego, La Jolla, Calif., Doherty TA; Section of Allergy and Immunology, Department of Medicine, University of California San Diego, La Jolla, Calif; Veterans Affairs San Diego Healthcare System, La Jolla, Calif. Electronic address: tdoherty@health.ucsd.edu.
Jazyk: angličtina
Zdroj: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2023 Nov; Vol. 152 (5), pp. 1330-1335.e1. Date of Electronic Publication: 2023 Aug 03.
DOI: 10.1016/j.jaci.2023.06.028
Abstrakt: Background: Aspirin-exacerbated respiratory disease (AERD) is associated with high levels of cysteinyl leukotrienes, prostaglandin D 2 , and low levels of prostaglandin E 2 . Further, 15-hydroxyeicosatetraenoic acid (15-HETE) levels may have predictive value in therapeutic outcomes of aspirin desensitization. Accumulation of nasal group 2 innate lymphoid cells (ILC2s) has been demonstrated during COX-1 inhibition in AERD, although the relationships between tissue ILC2 accumulation, reaction symptom severity, and novel lipid biomarkers are unknown.
Objective: We sought to determine whether novel lipid mediators are predictive of nasal ILC2 accumulation and symptom scores during COX-1 inhibitor challenge in patients with AERD.
Methods: Blood and nasal scraping samples from patients with AERD were collected at baseline and COX-1 inhibitor reaction and then processed for flow cytometry for nasal ILC2s and serum for lipidomic analysis.
Results: Eight patients with AERD who were undergoing aspirin desensitization were recruited. Of the 161 eicosanoids tested, 42 serum mediators were detected. Baseline levels of 15-HETE were negatively correlated with the change in numbers of airway ILC2s (r = -0.6667; P = .0428). Docosahexaenoic acid epoxygenase metabolite 19,20-dihydroxy-4Z,7Z,10Z,13Z,16Z-docosapentaenoic acid (19,20-diHDPA) was positively correlated with both changes in airway ILC2s (r = 0.7143; P = .0305) and clinical symptom scores (r = 0.5000; P = .0081).
Conclusion: Low levels of baseline 15-HETE predicted a greater accumulation of airway ILC2s in patients with AERD who were receiving COX-1 inhibition. Further, increases in the cytochrome P pathway metabolite 19,20-dihydroxy-4Z,7Z,10Z,13Z,16Z-docosapentaenoic acid (19,20-diHDPA) were associated with increased symptoms and nasal ILC2 accumulation. Future studies to assess how these mediators might control ILC2s may improve the understanding of AERD pathogenesis.
(Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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