Behavioral Impairments and Increased Risk of Cortical Atrophy Risk Scores Among World Trade Center Responders.

Autor:	Chen APF; Department of Neurobiology and Behavior, Renaissance School of Medicine, Stony Brook, NY, USA., Ismail Z; Hotchkiss Brain Institute and O'Brien Institute for Public Health, University of Calgary, Calgary, AB, Canada., Mann FD; Program in Public Health, Renaissance School of Medicine, Stony Brook, NY, USA.; Department of Family, Population, and Preventive Medicine, Renaissance School of Medicine, Stony Brook, NY, USA., Bromet EJ; Department of Psychiatry, Renaissance School of Medicine, Stony Brook, NY, USA., Clouston SAP; Program in Public Health, Renaissance School of Medicine, Stony Brook, NY, USA.; Department of Family, Population, and Preventive Medicine, Renaissance School of Medicine, Stony Brook, NY, USA., Luft BJ; Department of Medicine, Renaissance School of Medicine, Stony Brook, NY, USA.
Jazyk:	angličtina
Zdroj:	Journal of geriatric psychiatry and neurology [J Geriatr Psychiatry Neurol] 2024 Mar; Vol. 37 (2), pp. 114-124. Date of Electronic Publication: 2023 Aug 05.
DOI:	10.1177/08919887231195234
Abstrakt:	Objective: World Trade Center (WTC) responders are susceptible to both cognitive and neuropsychiatric impairments, particularly chronic posttraumatic stress disorder. The present study examined self-reported behavioral impairments in a sample of 732 WTC responders, 199 of whom were determined to have high risk of WTC-related cortical atrophy by an artificial neural network. Results: We found that responders at increased risk of cortical atrophy showed behavioral impairment across five domains: motivation, mood, disinhibition, empathy, and psychosis (14.6% vs 3.9% in the low-risk group; P = 3.90 × 10 -7 ). Factor analysis models revealed that responders at high risk of cortical atrophy tended to have deficits generalized across all aspects of behavioral impairment with focal dysfunction in sensory psychosis. We additionally describe how relationships are modulated by exposure severity and pharmacological treatments. Discussion: Our findings suggest a potential link between sensory deficits and the development of cortical atrophy in WTC responders and may indicate symptoms consistent with a clinical portrait of parietal dominant Alzheimer's disease or a related dementia (ADRD). Results underscore the importance of investigating neuropsychiatric symptomatology in clinical evaluations of possible ADRD. Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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