Henipavirus-induced neuropathogenesis in mice.

Autor: Edwards SJ; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australian Centre for Disease Preparedness (ACDP), 5 Portarlington Road, East Geelong, VIC, 3219, Australia; Department of Microbiology, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC, 3800, Australia. Electronic address: Sarah.Edwards@csiro.au., Rowe B; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australian Centre for Disease Preparedness (ACDP), 5 Portarlington Road, East Geelong, VIC, 3219, Australia., Reid T; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australian Centre for Disease Preparedness (ACDP), 5 Portarlington Road, East Geelong, VIC, 3219, Australia., Tachedjian M; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australian Centre for Disease Preparedness (ACDP), 5 Portarlington Road, East Geelong, VIC, 3219, Australia., Caruso S; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australian Centre for Disease Preparedness (ACDP), 5 Portarlington Road, East Geelong, VIC, 3219, Australia., Blasdell K; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australian Centre for Disease Preparedness (ACDP), 5 Portarlington Road, East Geelong, VIC, 3219, Australia., Watanabe S; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australian Centre for Disease Preparedness (ACDP), 5 Portarlington Road, East Geelong, VIC, 3219, Australia., Bergfeld J; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australian Centre for Disease Preparedness (ACDP), 5 Portarlington Road, East Geelong, VIC, 3219, Australia., Marsh GA; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australian Centre for Disease Preparedness (ACDP), 5 Portarlington Road, East Geelong, VIC, 3219, Australia; Department of Microbiology, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC, 3800, Australia.
Jazyk: angličtina
Zdroj: Virology [Virology] 2023 Oct; Vol. 587, pp. 109856. Date of Electronic Publication: 2023 Jul 29.
DOI: 10.1016/j.virol.2023.109856
Abstrakt: Hendra virus (HeV) and Nipah virus (NiV) are henipaviruses that can cause fatal encephalitis in humans. Many animal models have been used to study henipavirus pathogenesis. In the mouse, HeV infection has previously shown that intranasal challenge can lead to neurological infection, however mice similarly challenged with NiV show no evidence of virus infecting the brain. We generated recombinant HeV (rHeV) and NiV (rNiV) where selected proteins were switched to examine their role in neuroinvasion in the mouse. These viruses displayed similar growth kinetics when compared to wildtype in vitro. In the mouse, infection outcomes with recombinant virus did not differ to infection outcomes of wildtype viruses. Virus was detected in the brain of 5/30 rHeV-challenged mice, but not rNiV-challenged mice. To confirm the permissiveness of mouse neurons to these viruses, primary mouse neurons were successfully infected in vitro, suggesting that other pathobiological factors contribute to the differences in disease outcomes in mice.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Crown Copyright © 2023. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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