Sexual functioning, sexual enjoyment, and body image in Norwegian breast cancer survivors: a 12-year longitudinal follow-up study and comparison with the general female population.

Autor: Åsberg RE; Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, NTNU, Trondheim, Norway., Giskeødegård GF; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU, Trondheim, Norway.; Department of Breast and Endocrine Surgery, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway., Raj SX; Department of Oncology, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway., Karlsen J; Department of Oncology, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway.; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, Trondheim, Norway., Engstrøm M; Department of Breast and Endocrine Surgery, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway.; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, Trondheim, Norway., Salvesen Ø; Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU, Trondheim, Norway., Nilsen M; Department of Social Work, Faculty of Social and Educational Sciences, NTNU, Trondheim, Norway., Lundgren S; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, Trondheim, Norway., Reidunsdatter RJ; Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, NTNU, Trondheim, Norway.
Jazyk: angličtina
Zdroj: Acta oncologica (Stockholm, Sweden) [Acta Oncol] 2023 Jul; Vol. 62 (7), pp. 719-727. Date of Electronic Publication: 2023 Aug 03.
DOI: 10.1080/0284186X.2023.2238548
Abstrakt: Background: Given the scarcity of evidence concerning the long-term sexual health of breast cancer (BC) survivors (BC-Pop), we aimed to assess how BC treatments affect short- and long-term sexual functioning, sexual enjoyment, and body image, and compare with aged-matched women in the Norwegian general population (F-GenPop).
Material and Methods: The 349 patients in BC-Pop treated at Trondheim University Hospital in 2007-2014, were assessed in clinical controls at the hospital; before starting radiotherapy (T1, baseline), immediately after ending radiotherapy (T2), and after 3, 6, and 12 months (T3-T5), and at a long-term follow-up 7-12 years after baseline (T6). Meanwhile, F-GenPop included 2254 age-matched women in the Norwegian general population. The impact of BC treatment on sexual functioning was examined using a Linear Mixed Model. Sexual functioning, sexual enjoyment, and body image were assessed with the EORTC's QLQ-BR23 scales and compared between the populations in the four age groups (30-49, 50-59, 60-69, and 70+ years) using means with 95% confidence intervals and Student t -test. Linear regression, adjusted for age and comorbidity was applied to estimate individual scores.
Result: BC survivors treated with mastectomy had overall lower sexual functioning than patients who had received breast-conserving surgery ( p  = 0.017). Although BC survivors treated with chemotherapy had lower sexual functioning than those treated without chemotherapy at T1-T5 ( p  = 0.044), both groups showed the same level of functioning at T6. BC-Pop exhibited significantly poorer sexual functioning ( p  < 0.001), lower sexual enjoyment ( p  < 0.05), and better body image ( p  < 0.001) than F-GenPop in all age groups.
Conclusion: The impact of specific BC treatments on sexual functioning was modest; only mastectomy had a persistent negative influence. Nevertheless, all age groups in BC-Pop displayed significantly poorer sexual functioning than F-GenPop at both 12 months and up to 12 years after treatment.
Databáze: MEDLINE
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