Acute exposure to artificial light at night alters hippocampal vascular structure in mice.

Autor:	Bumgarner JR; Department of Neuroscience, Rockefeller Neuroscience Institute West Virginia University Morgantown, WV 26505, USA., Walker WH 2nd; Department of Neuroscience, Rockefeller Neuroscience Institute West Virginia University Morgantown, WV 26505, USA., Quintana DD; Department of Neuroscience, Rockefeller Neuroscience Institute West Virginia University Morgantown, WV 26505, USA., White RC; Department of Neuroscience, Rockefeller Neuroscience Institute West Virginia University Morgantown, WV 26505, USA., Richmond AA; Department of Neuroscience, Rockefeller Neuroscience Institute West Virginia University Morgantown, WV 26505, USA., Meléndez-Fernández OH; Department of Neuroscience, Rockefeller Neuroscience Institute West Virginia University Morgantown, WV 26505, USA., Liu JA; Department of Neuroscience, Rockefeller Neuroscience Institute West Virginia University Morgantown, WV 26505, USA., Becker-Krail DD; Department of Neuroscience, Rockefeller Neuroscience Institute West Virginia University Morgantown, WV 26505, USA., Walton JC; Department of Neuroscience, Rockefeller Neuroscience Institute West Virginia University Morgantown, WV 26505, USA., Simpkins JW; Department of Neuroscience, Rockefeller Neuroscience Institute West Virginia University Morgantown, WV 26505, USA., DeVries AC; Department of Neuroscience, Rockefeller Neuroscience Institute West Virginia University Morgantown, WV 26505, USA.; Department of Medicine, Division of Oncology/Hematology West Virginia University Morgantown, WV 26505, USA.; WVU Cancer Institute West Virginia University Morgantown, WV 26505 USA., Nelson RJ; Department of Neuroscience, Rockefeller Neuroscience Institute West Virginia University Morgantown, WV 26505, USA.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2023 May 29; Vol. 26 (7), pp. 106996. Date of Electronic Publication: 2023 May 29 (Print Publication: 2023).
DOI:	10.1016/j.isci.2023.106996
Abstrakt:	The structure and function of the cardiovascular system are modulated across the day by circadian rhythms, making this system susceptible to circadian rhythm disruption. Recent evidence demonstrated that short-term exposure to a pervasive circadian rhythm disruptor, artificial light at night (ALAN), increased inflammation and altered angiogenic transcripts in the hippocampi of mice. Here, we examined the effects of four nights of ALAN exposure on mouse hippocampal vascular networks. To do this, we analyzed 2D and 3D images of hippocampal vasculature and hippocampal transcriptomic profiles of mice exposed to ALAN. ALAN reduced vascular density in the CA1 and CA2/3 of female mice and the dentate gyrus of male mice. Network structure and connectivity were also impaired in the CA2/3 of female mice. These results demonstrate the rapid and potent effects of ALAN on cerebrovascular networks, highlighting the importance of ALAN mitigation in the context of health and cerebrovascular disease. Competing Interests: The authors declare no competing interests. (© 2023 The Authors.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu