Light disrupts social memory via a retina-to-supraoptic nucleus circuit.

Autor: Huang YF; Department of Life Science, National Taiwan University, Taipei, Taiwan., Liao PY; Department of Life Science, National Taiwan University, Taipei, Taiwan., Yu JH; Department of Life Science, National Taiwan University, Taipei, Taiwan., Chen SK; Department of Life Science, National Taiwan University, Taipei, Taiwan.
Jazyk: angličtina
Zdroj: EMBO reports [EMBO Rep] 2023 Oct 09; Vol. 24 (10), pp. e56839. Date of Electronic Publication: 2023 Aug 02.
DOI: 10.15252/embr.202356839
Abstrakt: The formation of social memory between individuals of the opposite sex is crucial for expanding mating options or establishing monogamous pair bonding. A specialized neuronal circuit that regulates social memory could enhance an individual's mating opportunities and provide a parallel pathway for computing social behaviors. While the influence of light exposure on various forms of memory, such as fear and object memory, has been studied, its modulation of social recognition memory remains unclear. Here, we demonstrate that acute exposure to light impairs social recognition memory (SRM) in mice. Unlike sound and touch stimuli, light inhibits oxytocin neurons in the supraoptic nucleus (SON) via M1 SON-projecting intrinsically photosensitive retinal ganglion cells (ipRGCs) and GABAergic neurons in the perinuclear zone of the SON (pSON). We further show that optogenetic activation of SON oxytocin neurons using channelrhodopsin is sufficient to enhance SRM performance, even under light conditions. Our findings unveil a dedicated neuronal circuit through which luminance affects SRM, utilizing a non-image-forming visual pathway, distinct from the canonical modulatory role of the oxytocin system.
(© 2023 The Authors.)
Databáze: MEDLINE
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