CCR4 predicts the efficacy of abatacept in rheumatoid arthritis patients through the estimation of Th17 and Treg cell abundance.

Autor:	Tanaka S; Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan., Etori K; Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan., Hattori K; Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan., Tamura J; Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan., Ikeda K; Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan., Kageyama T; Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan., Meguro K; Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan., Iwamoto T; Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan., Iwata A; Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan., Furuta S; Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan., Suto A; Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.; Graduate School of Medicine, Institute for Advanced Academic Research, Chiba, Japan., Suzuki K; Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan., Nakajima H; Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.; Chiba University, Synergy Institute for Futuristic Mucosal Vaccine Research and Development (cSIMVa), Chiba, Japan.
Jazyk:	angličtina
Zdroj:	Modern rheumatology [Mod Rheumatol] 2024 Jul 06; Vol. 34 (4), pp. 700-704.
DOI:	10.1093/mr/road077
Abstrakt:	Objectives: Predicting the efficacy of biological disease-modifying antirheumatic drugs is challenging. In this study, we aimed to explore markers that predict the efficacy of abatacept in rheumatoid arthritis (RA) patients. Methods: Thirty RA patients receiving abatacept were recruited, and peripheral blood mononuclear cells from the participants were subjected to DNA microarray analysis. The expression of CC chemokine receptor 4 (CCR4), which was selected by the result of DNA microarray, was determined by flow cytometry in 16 newly diagnosed treatment-naïve RA patients. CCR4 expression on each helper T-cell subset was also measured. Results: CCR4 was upregulated in the abatacept responder. The expression levels of CCR4 were significantly correlated with the improvement of the Clinical Disease Activity Index. CCR4 expression was predominantly observed in CD4+ T cells in peripheral blood mononuclear cells. The percentage of CCR4-expressing CD4+ T cells was significantly higher in RA patients than in healthy individuals. Interestingly, Th17 and Treg cells expressed high levels of CCR4 compared to non-Th17-related helper T cells. Conclusions: CCR4 is a Th17- and Treg-related gene, and the high CCR4 expression in peripheral blood samples may predict the efficacy of abatacept in RA. (© Japan College of Rheumatology 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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