Bioactive Compounds and Cardiac Fibrosis: Current Insight and Future Prospect.

Autor:	Majid A; Department of Physiology, College of Medicine, The University of Tennessee Health Science Center, Translational Research Building, Room 318H, 71 S. Manassas, Memphis, TN 38163, USA.; College of Graduate Health Sciences, The University of Tennessee Health Science Center, Memphis, TN 38163, USA., Hassan FO; Department of Physiology, College of Medicine, The University of Tennessee Health Science Center, Translational Research Building, Room 318H, 71 S. Manassas, Memphis, TN 38163, USA.; College of Graduate Health Sciences, The University of Tennessee Health Science Center, Memphis, TN 38163, USA., Hoque MM; Department of Physiology, College of Medicine, The University of Tennessee Health Science Center, Translational Research Building, Room 318H, 71 S. Manassas, Memphis, TN 38163, USA.; College of Graduate Health Sciences, The University of Tennessee Health Science Center, Memphis, TN 38163, USA., Gbadegoye JO; Department of Physiology, College of Medicine, The University of Tennessee Health Science Center, Translational Research Building, Room 318H, 71 S. Manassas, Memphis, TN 38163, USA.; College of Graduate Health Sciences, The University of Tennessee Health Science Center, Memphis, TN 38163, USA., Lebeche D; Department of Physiology, College of Medicine, The University of Tennessee Health Science Center, Translational Research Building, Room 318H, 71 S. Manassas, Memphis, TN 38163, USA.; College of Graduate Health Sciences, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Jazyk:	angličtina
Zdroj:	Journal of cardiovascular development and disease [J Cardiovasc Dev Dis] 2023 Jul 21; Vol. 10 (7). Date of Electronic Publication: 2023 Jul 21.
DOI:	10.3390/jcdd10070313
Abstrakt:	Cardiac fibrosis is a pathological condition characterized by excessive deposition of collagen and other extracellular matrix components in the heart. It is recognized as a major contributor to the development and progression of heart failure. Despite significant research efforts in characterizing and identifying key molecular mechanisms associated with myocardial fibrosis, effective treatment for this condition is still out of sight. In this regard, bioactive compounds have emerged as potential therapeutic antifibrotic agents due to their anti-inflammatory and antioxidant properties. These compounds exhibit the ability to modulate fibrogenic processes by inhibiting the production of extracellular matrix proteins involved in fibroblast to myofibroblast differentiation, or by promoting their breakdown. Extensive investigation of these bioactive compounds offers new possibilities for preventing or reducing cardiac fibrosis and its detrimental consequences. This comprehensive review aims to provide a thorough overview of the mechanisms underlying cardiac fibrosis, address the limitations of current treatment strategies, and specifically explore the potential of bioactive compounds as therapeutic interventions for the treatment and/or prevention of cardiac fibrosis.
Databáze:	MEDLINE
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