Ultrasound Enhancing Agents with Transthoracic Echocardiography for Maximal Wall Thickness in Hypertrophic Cardiomyopathy.

Autor:	Bois JP; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.; Department of Radiology, Mayo Clinic, Rochester, Minnesota., Ayoub C; Department of Cardiovascular Medicine, Mayo Clinic, Scottsdale, Arizona., Geske JB; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota., Wong YW; Department of Cardiovascular Medicine, Mayo Clinic, Scottsdale, Arizona., Abbasi MA; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota., Foley TA; Department of Radiology, Mayo Clinic, Rochester, Minnesota., Mulvagh SL; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota., Scott CG; Department of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota., Ommen SR; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota., Pellikka PA; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota.
Jazyk:	angličtina
Zdroj:	Mayo Clinic proceedings. Innovations, quality & outcomes [Mayo Clin Proc Innov Qual Outcomes] 2023 Jul 19; Vol. 7 (4), pp. 309-319. Date of Electronic Publication: 2023 Jul 19 (Print Publication: 2023).
DOI:	10.1016/j.mayocpiqo.2023.06.002
Abstrakt:	Objectives: To determine whether ultrasound enhancing agent (UEA) changes maximal wall thickness (WT) in hypertrophic cardiomyopathy (HCM), and if it improves correlation with magnetic resonance imaging (MRI). Patients and Methods: A total of 107 patients with HCM were prospectively enrolled at a single tertiary referral center between July 10, 2014, and August 31, 2017, and underwent transthoracic echocardiography (TTE) with and without UEA and MRI. Maximal WT measurements were compared, and variability among the 3 modalities was evaluated using a simple linear regression analysis and paired t tests and Bland-Altman plots. Interobserver variability for each technique was assessed. Results: Most (63%) of cardiac imagers found UEA helpful in determining maximal WT by TTE, with 49% reporting change in WT. Of 52 patients where UEA changed WT measurement, 32 (62%) reported an increase and 20 (38%) reported a decrease in WT. The UEA did not alter the median discrepancy in WT between MRI and TTE. However, where UEA increased reported WT, the difference between MRI and TTE improved in 79% of cases ( P =.001) from 2.0-0.5mm. In those with scar on MRI, UEA improved agreement of WT between TTE and MRI compared with that of TTE without UEA (79% vs 39%; P =.011). Interclass correlation coefficient for WT for TTE without UEA, with UEA, and MRI was 0.84; (95% CI, 0.61-0.92), 0.88; (95%CI, 0.82-0.92), and 0.97; (95%CI, 0.96-0.98), respectively. Conclusion: Although use of UEA did not eliminate differences in WT discrepancy between modalities, the addition of UEA to TTE aided in WT determination and improved correlation with MRI in those with greater WT and in all patients with myocardial scars. Competing Interests: The authors have no conflicts of interest to disclose. (© 2023 The Authors.)
Databáze:	MEDLINE
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