Advance Consent in Acute Stroke Trials: Survey of Canadian Research Ethics Board Chairs.

Autor: Seeger R; Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Udoh U; Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON, Canada., Dewar B; Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON, Canada., Nicholls S; Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON, Canada., Fedyk M; School of Medicine, University of California, Davis, Davis, CA, USA., Fahed R; Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON, Canada.; Division of Neurology, Department of Medicine, The Ottawa Hospital, Ottawa, ON, Canada., Perry J; Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON, Canada.; Department of Emergency Medicine, The Ottawa Hospital, Ottawa, ON, Canada., Hill MD; Department of Clinical Neurosciences, University of Calgary and Calgary Stroke Program, Calgary, AB, Canada., Menon B; Department of Clinical Neurosciences, University of Calgary and Calgary Stroke Program, Calgary, AB, Canada., Swartz RH; Department of Medicine, University of Toronto & Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Poppe AY; Department of Neurosciences, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada., Gocan S; Division of Neurology, Department of Medicine, The Ottawa Hospital, Ottawa, ON, Canada., Brehaut J; Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON, Canada., Dainty K; Department of Research and Innovation, North York General Hospital, Toronto, ON, Canada.; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada., Shepherd V; Centre for Trials Research, Cardiff University, Cardiff, UK., Dowlatshahi D; Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON, Canada.; Division of Neurology, Department of Medicine, The Ottawa Hospital, Ottawa, ON, Canada., Shamy M; Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON, Canada.; Division of Neurology, Department of Medicine, The Ottawa Hospital, Ottawa, ON, Canada.
Jazyk: angličtina
Zdroj: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques [Can J Neurol Sci] 2024 Mar; Vol. 51 (2), pp. 285-288. Date of Electronic Publication: 2023 Jul 24.
DOI: 10.1017/cjn.2023.247
Abstrakt: Advance consent could allow individuals at high risk of stroke to provide consent before they might become eligible for enrollment in acute stroke trials. This survey explores the acceptability of this novel technique to Canadian Research Ethics Board (REB) chairs that review acute stroke trials. Responses from 15 REB chairs showed that majority of respondents expressed comfort approving studies that adopt advance consent. There was no clear preference for advance consent over deferral of consent, although respondents expressed significant concern with broad rather than trial-specific advance consent. These findings shed light on the acceptability of advance consent to Canadian ethics regulators.
Databáze: MEDLINE