Evolving Approach to Clinical Cytometry for Immunodeficiencies and Other Immune Disorders.

Autor:	Sadighi Akha AA; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Csomós K; Division of Pediatric Allergy/Immunology, University of South Florida, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA., Ujházi B; Division of Pediatric Allergy/Immunology, University of South Florida, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA., Walter JE; Division of Pediatric Allergy/Immunology, University of South Florida, Johns Hopkins All Children's Hospital, St. Petersburg, FL, USA., Kumánovics A; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Electronic address: kumanovics.attila@mayo.edu.
Jazyk:	angličtina
Zdroj:	Clinics in laboratory medicine [Clin Lab Med] 2023 Sep; Vol. 43 (3), pp. 467-483. Date of Electronic Publication: 2023 Jun 09.
DOI:	10.1016/j.cll.2023.05.002
Abstrakt:	Primary immunodeficiencies were initially identified on the basis of recurrent, severe or unusual infections. Subsequently, it was noted that these diseases can also manifest with autoimmunity, autoinflammation, allergy, lymphoproliferation and malignancy, hence a conceptual change and their renaming as inborn errors of immunity. Ongoing advances in flow cytometry provide the opportunity to expand or modify the utility and scope of existing laboratory tests in this field to mirror this conceptual change. Here we have used the B cell subset, variably known as CD21low B cells, age-associated B cells and T-bet+ B cells, as an example to demonstrate this possibility. (Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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