Structure elucidation of Keroplatus (Diptera:Keroplatidae) fungus gnat oxyluciferin.

Autor: Kotlobay AA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia. Electronic address: alexey_kotlobay@ibch.ru., Dubinnyi MA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia; Department of Biological and Medical Physics, Moscow Institute of Physics and Technology (State University), 9 Institutskiy per., Dolgoprudny, Moscow, 141700, Russia., Kovalchuk SI; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia., Makhin AP; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia; Higher Chemical College of the Russian Academy of Sciences, D. Mendeleev University of Chemical Technology of Russia, 9 Miusskaya sq., Moscow, 125047, Russia., Miturich VS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia; Faculty of Chemistry, National Research University Higher School of Economics, 7 Vavilova str., Moscow, 119048, Russia., Lyakhovich MS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia., Fontaine DM; Department of Chemistry, Connecticut College, New London, CT, 06320, USA., Southworth TL; Department of Chemistry, Connecticut College, New London, CT, 06320, USA., Shmygarev VI; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia., Yatskin ON; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia., Branchini BR; Department of Chemistry, Connecticut College, New London, CT, 06320, USA., Yampolsky IV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia; Institute of Translational Medicine, Pirogov Russian National Research Medical University, 1 Ostrovityanova str., Moscow, 117997, Russia., Kaskova ZM; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia; Institute of Translational Medicine, Pirogov Russian National Research Medical University, 1 Ostrovityanova str., Moscow, 117997, Russia. Electronic address: zkaskova@ibch.ru.
Jazyk: angličtina
Zdroj: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2023 Oct 08; Vol. 676, pp. 1-5. Date of Electronic Publication: 2023 Jul 17.
DOI: 10.1016/j.bbrc.2023.07.035
Abstrakt: Bioluminescence of insects is a well-known natural phenomenon in the focus of interest of scientific research. While the mechanisms of bioluminescence in Coleoptera have been extensively studied, there is a lack of information about the chemistry of light emission in Diptera species. Here we report the Keroplatus spp. oxyluciferin structure elucidation and identification as 3-hydroxykynurenic acid. Additionally, the present study provides the first direct evidence of the relationship between the bioluminescent systems of Orfelia and Keroplatus. However, the properties of the putative Orfelia oxyluciferin suggest that the light emission mechanisms are not identical.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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