Association between smoking and colorectal cancer in Eastern Mediterranean Regional Office (EMRO): A systematic review and meta-analysis.

Autor: Keivanlou MH; Gastrointestinal and Liver Diseases Research Center, Guilan University, Rasht, Iran., Amini-Salehi E; Gastrointestinal and Liver Diseases Research Center, Guilan University, Rasht, Iran., Hassanipour S; Gastrointestinal and Liver Diseases Research Center, Guilan University, Rasht, Iran., Mahapatro A; School of Medicine, Hi-Tech Medical College and Hospital, Rourkela, Odisha, India., Raghuma N; School of Medicine, GSL Medical College and General Hospital, Rajamahendravaram, Andhra Pradesh, India., Joukar F; Gastrointestinal and Liver Diseases Research Center, Guilan University, Rasht, Iran., Letafatkar N; Gastrointestinal and Liver Diseases Research Center, Guilan University, Rasht, Iran., Habibi A; Gastrointestinal and Liver Diseases Research Center, Guilan University, Rasht, Iran., Norouzi N; Gastrointestinal and Liver Diseases Research Center, Guilan University, Rasht, Iran., Aleali MS; Gastrointestinal and Liver Diseases Research Center, Guilan University, Rasht, Iran., Javid M; Gastrointestinal and Liver Diseases Research Center, Guilan University, Rasht, Iran., Mirdamadi A; Gastrointestinal and Liver Diseases Research Center, Guilan University, Rasht, Iran., Mansour-Ghanaei F; Gastrointestinal and Liver Diseases Research Center, Guilan University, Rasht, Iran.
Jazyk: angličtina
Zdroj: Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association [Saudi J Gastroenterol] 2023 Jul-Aug; Vol. 29 (4), pp. 204-211.
DOI: 10.4103/sjg.sjg_163_23
Abstrakt: Background: Smoking poses a significant risk for colorectal cancer (CRC), considered the third leading reason for cancer-related deaths worldwide. However, there has been limited research on the relationship between smoking and CRC in the Eastern Mediterranean Regional Office (EMRO). Therefore, a meta-analysis was conducted to combine available data and gain a comprehensive understanding of the relationship between smoking and CRC in EMRO.
Methods: Two independent researchers searched PubMed, Scopus, and Web of Science until December 2022. The included studies were checked for risk of bias administering the Newcastle-Ottawa scale. Heterogeneity was evaluated using I2 statistics and the Cochrane test. Publication bias was determined through funnel plot analysis and Egger's regression test. Additionally, a meta-regression analysis explored the impact of a country's Human Development Index (HDI) on the relationship between smoking and CRC.
Results: The final analysis included 26 studies, revealing a significant association between smoking and CRC (OR = 1.40; 95% CI: 1.11 - 1.78; P = 0.004). Moreover, smoking had a more pronounced adverse effect on CRC in countries with higher HDIs compared to those with lower HDIs (OR = 1.30; 95% CI: 0.99 - 1.71; P = 0.054).
Conclusions: Our findings underscore the importance of implementing smoking cessation programs and policies in EMRO countries, as they demonstrate a positive relationship between smoking and the risk of CRC. Furthermore, the results suggest that a country's level of human development may influence the association between smoking and CRC. Further research is needed to investigate this potential connection and develop targeted public health interventions.
Competing Interests: None
Databáze: MEDLINE
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