Induction of bronchus-associated lymphoid tissue is an early life adaptation for promoting human B cell immunity.

Autor: Matsumoto R; Department of Surgery, Columbia University Irving Medical Center, New York, NY, USA., Gray J; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Rybkina K; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Oppenheimer H; Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev, Be'er-Sheva, Israel.; The National Institute for Biotechnology in the Negev, Ben-Gurion University of Negev, Be'er-Sheva, Israel., Levy L; Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev, Be'er-Sheva, Israel.; The National Institute for Biotechnology in the Negev, Ben-Gurion University of Negev, Be'er-Sheva, Israel., Friedman LM; Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev, Be'er-Sheva, Israel.; The National Institute for Biotechnology in the Negev, Ben-Gurion University of Negev, Be'er-Sheva, Israel., Khamaisi M; Department of Human Biology, University of Haifa, Haifa, Israel., Meng W; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Rosenfeld AM; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Guyer RS; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Bradley MC; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Chen D; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA., Atkinson MA; Department of Pathology, Immunology and Laboratory Medicine, University of Florida Diabetes Institute, Gainesville, FL, USA., Brusko TM; Department of Pathology, Immunology and Laboratory Medicine, University of Florida Diabetes Institute, Gainesville, FL, USA., Brusko M; Department of Pathology, Immunology and Laboratory Medicine, University of Florida Diabetes Institute, Gainesville, FL, USA., Connors TJ; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA., Luning Prak ET; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Hershberg U; Department of Human Biology, University of Haifa, Haifa, Israel., Sims PA; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Biochemistry & Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, USA., Hertz T; Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev, Be'er-Sheva, Israel.; The National Institute for Biotechnology in the Negev, Ben-Gurion University of Negev, Be'er-Sheva, Israel.; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Farber DL; Department of Surgery, Columbia University Irving Medical Center, New York, NY, USA. df2396@cumc.columbia.edu.; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA. df2396@cumc.columbia.edu.
Jazyk: angličtina
Zdroj: Nature immunology [Nat Immunol] 2023 Aug; Vol. 24 (8), pp. 1370-1381. Date of Electronic Publication: 2023 Jul 17.
DOI: 10.1038/s41590-023-01557-3
Abstrakt: Infants and young children are more susceptible to common respiratory pathogens than adults but can fare better against novel pathogens like severe acute respiratory syndrome coronavirus 2. The mechanisms by which infants and young children mount effective immune responses to respiratory pathogens are unknown. Through investigation of lungs and lung-associated lymph nodes from infant and pediatric organ donors aged 0-13 years, we show that bronchus-associated lymphoid tissue (BALT), containing B cell follicles, CD4 + T cells and functionally active germinal centers, develop during infancy. BALT structures are prevalent around lung airways during the first 3 years of life, and their numbers decline through childhood coincident with the accumulation of memory T cells. Single-cell profiling and repertoire analysis reveals that early life lung B cells undergo differentiation, somatic hypermutation and immunoglobulin class switching and exhibit a more activated profile than lymph node B cells. Moreover, B cells in the lung and lung-associated lymph nodes generate biased antibody responses to multiple respiratory pathogens compared to circulating antibodies, which are mostly specific for vaccine antigens in the early years of life. Together, our findings provide evidence for BALT as an early life adaptation for mobilizing localized immune protection to the diverse respiratory challenges during this formative life stage.
(© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Databáze: MEDLINE
Externí odkaz: