Screening Tools for Sarcopenia in Mild to Moderate Parkinson's Disease: Assessing the Accuracy of SARC-F and Calf Circumference.

Autor: de Luna JRG; Department of Clinical Medicine, Division of Geriatrics, Universidade Federal do Ceará, Fortaleza, Brazil., Lima DP; Department of Clinical Medicine, Division of Geriatrics, Universidade Federal do Ceará, Fortaleza, Brazil.; Medical School of Universidade de Fortaleza, Fortaleza, Brazil., Gomes VC; Clinical Research Unit of Hospital Universitário Walter Cantídio, Universidade Federal do Ceará/Empresa Brasileira de Serviços Hospitalares (EBSERH), Fortaleza, Brazil., de Almeida SB; Clinical Research Unit of Hospital Universitário Walter Cantídio, Universidade Federal do Ceará/Empresa Brasileira de Serviços Hospitalares (EBSERH), Fortaleza, Brazil., Monteiro PA; Clinical Research Unit of Hospital Universitário Walter Cantídio, Universidade Federal do Ceará/Empresa Brasileira de Serviços Hospitalares (EBSERH), Fortaleza, Brazil., Viana-Júnior AB; Clinical Research Unit of Hospital Universitário Walter Cantídio, Universidade Federal do Ceará/Empresa Brasileira de Serviços Hospitalares (EBSERH), Fortaleza, Brazil., Marques da Silva TA; Clinical Research Unit of Hospital Universitário Walter Cantídio, Universidade Federal do Ceará/Empresa Brasileira de Serviços Hospitalares (EBSERH), Fortaleza, Brazil., Gradvohl LB; Medical School of Universidade de Fortaleza, Fortaleza, Brazil., Bruno LB; Medical School of Universidade de Fortaleza, Fortaleza, Brazil., Lindsay Silva Marques M; Clinical Research Unit of Hospital Universitário Walter Cantídio, Universidade Federal do Ceará/Empresa Brasileira de Serviços Hospitalares (EBSERH), Fortaleza, Brazil., Cunha LCV; Clinical Research Unit of Hospital Universitário Walter Cantídio, Universidade Federal do Ceará/Empresa Brasileira de Serviços Hospitalares (EBSERH), Fortaleza, Brazil., Feitosa CX; Medical School of Universidade de Fortaleza, Fortaleza, Brazil., Braga-Neto P; Department of Clinical Medicine, Division of Neurology, Universidade Federal do Ceará, Fortaleza, Brazil.; Center of Health Sciences, Universidade Estadual do Ceará, Fortaleza, Brazil., Roriz-Filho JS; Department of Clinical Medicine, Division of Geriatrics, Universidade Federal do Ceará, Fortaleza, Brazil., Montenegro-Júnior RM; Department of Clinical Medicine, Division of Endocrinology and Metabolism, Universidade Federal do Ceará, Fortaleza, Brazil.
Jazyk: angličtina
Zdroj: Journal of Parkinson's disease [J Parkinsons Dis] 2023; Vol. 13 (6), pp. 947-959.
DOI: 10.3233/JPD-230010
Abstrakt: Background: Parkinson's disease (PD) and sarcopenia share similar pathophysiological mechanisms.
Objective: Estimate the prevalence of sarcopenia in PD patients and describe clinical and demographic features associated with sarcopenia.
Methods: A cross-sectional study was carried out at a tertiary public hospital in Brazil. A modified HY scale of stage 1 to 3, being at least 40 years old and having the ability to stand and walk unassisted were required for eligibility. We evaluated physical performance and muscle mass using DEXA.
Results: The study population comprised 124 patients, of which 53 (42.7%) were women. The mean age and mean disease duration were 65.8±10.5 and 10.1±5.8 years, respectively. The mean handgrip strength of 20.4±6.9 in woman and 34.6±8.4 kg in men. Moreover, 50.8% patients had positive SARC-F, 20% patients had probable sarcopenia, 9.6% confirmed sarcopenia, and 16.8% patients showed low muscle mass quantity measured by DEXA. Lower Levodopa Equivalent Dosage (LED) and calf circumference (CC) were independently associated with confirmed sarcopenia. LLED, higher MDS-UPDRS Part III, and lower MMSE scores were independently associated with probable sarcopenia. The CC demonstrated accuracy to identify PD patients with confirmed sarcopenia with a cut-off of <31 cm in women and <34 cm in men.
Conclusion: We found low prevalence of confirmed sarcopenia among PD patients. We propose that healthcare providers introduce measuring CC, which is a quick and inexpensive method to assess for sarcopenia in PD patients.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje