Could Endothelin-1 Be a Promising Neurohormonal Biomarker in Acute Heart Failure?

Autor: Dmour BA; Department of Internal Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iași, Romania., Costache AD; Department of Internal Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iași, Romania.; Department of Cardiovascular Rehabilitation, Clinical Rehabilitation Hospital, 700661 Iași, Romania., Dmour A; Department of Orthopedics and Traumatology, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iași, Romania.; Department of Orthopaedics and Traumatology, 'St. Spiridon' County Clinical Emergency Hospital, 700111 Iași, Romania., Huzum B; Department of Orthopaedics and Traumatology, 'St. Spiridon' County Clinical Emergency Hospital, 700111 Iași, Romania.; Department of Physiology, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iași, Romania., Duca ȘT; Department of Internal Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iași, Romania.; Cardiology Clinic, 'St. Spiridon' County Clinical Emergency Hospital, 700111 Iași, Romania., Chetran A; Department of Internal Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iași, Romania.; Cardiology Clinic, 'St. Spiridon' County Clinical Emergency Hospital, 700111 Iași, Romania., Miftode RȘ; Department of Internal Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iași, Romania.; Cardiology Clinic, 'St. Spiridon' County Clinical Emergency Hospital, 700111 Iași, Romania., Afrăsânie I; Department of Internal Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iași, Romania.; Cardiology Clinic, 'St. Spiridon' County Clinical Emergency Hospital, 700111 Iași, Romania., Tuchiluș C; Department of Microbiology, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iași, Romania.; Microbiology Laboratory, 'St. Spiridon' County Clinical Emergency Hospital, 700111 Iași, Romania., Cianga CM; Immunology Laboratory, 'St. Spiridon' County Clinical Emergency Hospital, 700111 Iași, Romania.; Department of Immunology, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iași, Romania., Botnariu G; Unit of Diabetes, Nutrition and Metabolic Diseases, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iași, Romania.; Clinical Center of Diabetes, Nutrition and Metabolic Diseases, 'St. Spiridon' County Clinical Emergency Hospital, 700111 Iași, Romania., Șerban LI; Department of Physiology, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iași, Romania., Ciocoiu M; Department of Morpho-Functional Sciences II, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iași, Romania., Bădescu CM; Department of Internal Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iași, Romania.; Internal Medicine Clinic, 'St. Spiridon' County Clinical Emergency Hospital, 700111 Iași, Romania., Costache II; Department of Internal Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iași, Romania.; Cardiology Clinic, 'St. Spiridon' County Clinical Emergency Hospital, 700111 Iași, Romania.
Jazyk: angličtina
Zdroj: Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2023 Jul 05; Vol. 13 (13). Date of Electronic Publication: 2023 Jul 05.
DOI: 10.3390/diagnostics13132277
Abstrakt: Acute heart failure (AHF) is a life-threatening condition with high morbidity and mortality. Even though this pathology has been extensively researched, there are still challenges in establishing an accurate and early diagnosis, determining the long- and short-term prognosis and choosing a targeted therapeutic strategy. The use of reliable biomarkers to support clinical judgment has been shown to improve the management of AHF patients. Despite a large pool of interesting candidate biomarkers, endothelin-1 (ET-1) appears to be involved in multiple aspects of AHF pathogenesis that include neurohormonal activation, cardiac remodeling, endothelial dysfunction, inflammation, atherosclerosis and alteration of the renal function. Since its discovery, numerous studies have shown that the level of ET-1 is associated with the severity of symptoms and cardiac dysfunction in this pathology. The purpose of this paper is to review the existing information on ET-1 and answer the question of whether this neurohormone could be a promising biomarker in AHF.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje