Liver fibrosis is associated with an increased risk of non-fatal myocardial infarction.

Autor: Riccio A; Department of Clinical and Molecular Medicine, University of Rome-Sapienza, Rome, Italy., Mazzanti C; Department of Clinical and Molecular Medicine, University of Rome-Sapienza, Rome, Italy., Vero L; Department of Clinical and Molecular Medicine, University of Rome-Sapienza, Rome, Italy., Fiorentino TV; Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy., Succurro E; Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy., Rubino M; Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy., Massimino M; Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy., Mannino GC; Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy., Sciacqua A; Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy., Andreozzi F; Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy., Cefalo CMA; Department of Clinical and Molecular Medicine, University of Rome-Sapienza, Rome, Italy., Sesti G; Department of Clinical and Molecular Medicine, University of Rome-Sapienza, Rome, Italy.
Jazyk: angličtina
Zdroj: European journal of clinical investigation [Eur J Clin Invest] 2023 Nov; Vol. 53 (11), pp. e14061. Date of Electronic Publication: 2023 Jul 12.
DOI: 10.1111/eci.14061
Abstrakt: Introduction: Liver fibrosis is a risk factor for liver-related adverse outcomes and cardiovascular disease (CVD). Recently, the non-invasive Hepamet fibrosis score (HFS) has been validated as a tool capable to identify with good diagnostic accuracy subjects with advanced liver fibrosis. It is unsettled whether HFS is capable to identify individuals at higher risk of CVD. To investigate whether individuals with liver fibrosis measured with HFS have higher risk of myocardial infarction (MI) in adults participating in the CATAnzaro MEtabolic RIsk factors (CATAMERI) study.
Methods: Participants (n = 2948) were divided into three groups according to HFS: low risk of fibrosis (<0.12); intermediate risk of fibrosis (≥0.12 to <0.47); high risk of fibrosis (≥0.47). The association between the liver fibrosis risk and MI was analysed by a logistic regression analysis.
Results: As compared with those having the lowest risk (5.3%), a higher proportion of subjects with moderate or high risk of liver fibrosis had MI (12.9% and 24.4%, respectively; p < 0.001). In a logistic regression analysis, individuals at increased risk of liver fibrosis exhibited a threefold increased risk of having MI as compared to those with low risk (OR 3.18; 95% CI 1.31-7.70) independently of confounders including smoking, cholesterol, triglycerides, anti-hypertensive, lipid-lowering and glucose-lowering therapies.
Conclusions: In this cross-sectional study, individuals with higher values of HFS show a higher risk of MI, suggesting that HFS may be a useful tool to identify not only individuals with liver fibrosis but also those at the increased risk of CVD.
(© 2023 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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