Axo-axonic cells in neuropsychiatric disorders: a systematic review.

Autor:	Vivien J; Université de Bordeaux, Inserm Neurocentre Magendie U1215, Bordeaux, France., El Azraoui A; Université de Bordeaux, Inserm Neurocentre Magendie U1215, Bordeaux, France.; Univ Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR 5297, Bordeaux, France., Lheraux C; Université de Bordeaux, Inserm Neurocentre Magendie U1215, Bordeaux, France., Lanore F; Centre Hospitalier Charles Perrens, Inserm Neurocentre Magendie U1215, Bordeaux, France., Aouizerate B; Université de Bordeaux, Inserm Neurocentre Magendie U1215, Bordeaux, France.; Centre Hospitalier Charles Perrens, Inserm Neurocentre Magendie U1215, Bordeaux, France.; INRAE, Bordeaux INP, NutriNeuro, UMR 1286, Bordeaux, France., Herry C; Université de Bordeaux, Inserm Neurocentre Magendie U1215, Bordeaux, France., Humeau Y; Univ Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR 5297, Bordeaux, France., Bienvenu TCM; Université de Bordeaux, Inserm Neurocentre Magendie U1215, Bordeaux, France.; Centre Hospitalier Charles Perrens, Inserm Neurocentre Magendie U1215, Bordeaux, France.
Jazyk:	angličtina
Zdroj:	Frontiers in cellular neuroscience [Front Cell Neurosci] 2023 Jun 26; Vol. 17, pp. 1212202. Date of Electronic Publication: 2023 Jun 26 (Print Publication: 2023).
DOI:	10.3389/fncel.2023.1212202
Abstrakt:	Imbalance between excitation and inhibition in the cerebral cortex is one of the main theories in neuropsychiatric disorder pathophysiology. Cortical inhibition is finely regulated by a variety of highly specialized GABAergic interneuron types, which are thought to organize neural network activities. Among interneurons, axo-axonic cells are unique in making synapses with the axon initial segment of pyramidal neurons. Alterations of axo-axonic cells have been proposed to be implicated in disorders including epilepsy, schizophrenia and autism spectrum disorder. However, evidence for the alteration of axo-axonic cells in disease has only been examined in narrative reviews. By performing a systematic review of studies investigating axo-axonic cells and axo-axonic communication in epilepsy, schizophrenia and autism spectrum disorder, we outline convergent findings and discrepancies in the literature. Overall, the implication of axo-axonic cells in neuropsychiatric disorders might have been overstated. Additional work is needed to assess initial, mostly indirect findings, and to unravel how defects in axo-axonic cells translates to cortical dysregulation and, in turn, to pathological states. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Vivien, El Azraoui, Lheraux, Lanore, Aouizerate, Herry, Humeau and Bienvenu.)
Databáze:	MEDLINE
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