Substantial changes in inflammatory and cardiovascular biomarkers in patients with autonomous cortisol secretion.

Autor:	Ueland GÅ; Department of Medicine, Haukeland University Hospital, Jonas Lies vei 65, Bergen 5021, Norway., Methlie P; Department of Medicine, Haukeland University Hospital, Jonas Lies vei 65, Bergen 5021, Norway.; Department of Clinical Science, University of Bergen, Haukelandsveien 9, Bergen 5009, Norway., Heie A; Department of Surgery, Haukeland University Hospital, Jonas Liesvei 65, Bergen 5021, Norway., Meling Stokland AE; Department of Clinical Science, University of Bergen, Haukelandsveien 9, Bergen 5009, Norway.; Department of Medicine, Stavanger University Hospital, Gerd-Ragna Bloch Thorsens gate 8, Stavanger 4019, Norway., Dahle AL; Department of Medicine, Haugesund Hospital, Karmsundgata 120, 5528 Haugesund, Norway., Sævik ÅB; Department of Clinical Science, University of Bergen, Haukelandsveien 9, Bergen 5009, Norway., Løvås K; Department of Medicine, Haukeland University Hospital, Jonas Lies vei 65, Bergen 5021, Norway., Husebye ES; Department of Medicine, Haukeland University Hospital, Jonas Lies vei 65, Bergen 5021, Norway.; Department of Clinical Science, University of Bergen, Haukelandsveien 9, Bergen 5009, Norway.
Jazyk:	angličtina
Zdroj:	European journal of endocrinology [Eur J Endocrinol] 2023 Jul 20; Vol. 189 (1), pp. 78-86.
DOI:	10.1093/ejendo/lvad076
Abstrakt:	Objective: To map inflammatory biomarkers in patients with autonomous cortisol secretion (ACS) and overt Cushing syndrome (CS). Method: Observational study including serum from prospectively included patients with ACS (n = 63), adrenal CS (n = 2), pituitary CS (n = 8), and healthy subjects (n = 120). Serum samples were analysed for 92 inflammatory biomarkers using proximity extension assay (OLINK). Results: Combined, the ACS and CS patients displayed significant differences in levels of 49/92 inflammatory biomarkers (46 increased/3 decreased) compared with healthy controls. No differences in biomarker levels were found between ACS and overt CS, and none of the biomarkers correlated with the degree of hypercortisolism. Postoperative samples were available for 17 patients, median 24 months (range 6-40) after surgery and biochemical curation. There was no significant normalization of the biomarkers postoperatively. Conclusion: There was a systemic rise in inflammatory biomarkers in patients with ACS and CS, not correlated to the degree of hypercortisolism. These biomarkers were not normalized following biochemical cure. (© The Author(s) 2023. Published by Oxford University Press on behalf of European Society of Endocrinology.)
Databáze:	MEDLINE
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