Werner syndrome associated with poorly differentiated thyroid carcinoma and systemic sclerosis-like skin manifestations: A case report.

Autor:	Sugawara E; Department of Rheumatology, Tonan Hospital, Sapporo, Japan., Shibata Y; Department of Rheumatology, Tonan Hospital, Sapporo, Japan., Katsumata K; Department of Rheumatology, Tonan Hospital, Sapporo, Japan.
Jazyk:	angličtina
Zdroj:	Modern rheumatology case reports [Mod Rheumatol Case Rep] 2023 Dec 29; Vol. 8 (1), pp. 95-100.
DOI:	10.1093/mrcr/rxad039
Abstrakt:	Werner syndrome (WS) is an autosomal recessive disorder characterised by premature ageing. WS patients often experience scleroderma-like manifestation including skin sclerosis and skin ulcer, making it difficult to differentiate WS from systemic sclerosis (SSc). Moreover, there is a high incidence of malignancy and arteriosclerosis-related disease in WS patients. We herein describe a 36-year-old woman with WS who had poorly differentiated thyroid carcinoma, one of the rare phenotypes of thyroid tumour. This case suggested the importance to distinguish WS from SSc and early diagnosis of malignancy. (© Japan College of Rheumatology 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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