Bioassay-Guided Isolation and Identification of Antiplasmodial Compounds from the Stem Bark of Clausena excavata.

Autor: Seephonkai P; Multidisciplinary Research Unit of Pure and Applied Chemistry, Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahasarakham University, Khamriang, Kantarawichai, Maha Sarakham, Thailand., Kaewtong C; Multidisciplinary Research Unit of Pure and Applied Chemistry, Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahasarakham University, Khamriang, Kantarawichai, Maha Sarakham, Thailand., Wangchuk P; Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns Campus, Smithfield, Queenland, Australia., Jearawuttanakul K; Excellent Center for Drug Discovery, Faculty of Science, Mahidol University, Bangkok, Thailand., Kanjanasirirat P; Excellent Center for Drug Discovery, Faculty of Science, Mahidol University, Bangkok, Thailand., Borwornpinyo S; Excellent Center for Drug Discovery, Faculty of Science, Mahidol University, Bangkok, Thailand., Khulmanee T; Drug Research Unit for Malaria, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Patrapuvich R; Drug Research Unit for Malaria, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Jazyk: angličtina
Zdroj: Planta medica [Planta Med] 2023 Oct; Vol. 89 (12), pp. 1165-1169. Date of Electronic Publication: 2023 Jul 06.
DOI: 10.1055/a-2112-6631
Abstrakt: Clausena excavata is a medicinal plant widely distributed in Southeast Asia. It is used for a variety of indications, including to treat malaria. In our present study, a phytochemical study of the methanol extract from the stem bark of C. excavata led to the isolation of five pyranocoumarins, nordentatin (1: ), dentatin (2: ), kinocoumarin (3: ), clausarin (4: ), and clausenidin (5: ), and a coumarin, 8-hydroxy-3″,4″-dihydrocapnolactone-2',3'-diol (6: ). The isolation of compound 6: from C. excavata and the antiplasmodial activities against a multidrug-resistant K1 strain of Plasmodium falciparum of 1, 3: , and 5: were reported for the first time. Compounds 3: and 4: exhibited potent antiplasmodial activities with EC 50 values of 1.10 and 0.58 µM, respectively, while 1: and 5: had EC 50 values of 5.62 and 7.15 µM, respectively. A prenyl group attached to the C-3 or C-12 position on the pyranocoumarin ring probably plays an important role on the activity. A hydroxyl group at the C-10 position is also likely to enhance the activity.
Competing Interests: The authors declare that they have no conflict of interest.
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Databáze: MEDLINE
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