Evaluation of safety and performance of a new prototype self-expandable nitinol venous stent in an ovine model.

Autor:	Barbati ME; Clinic of Vascular and Endovascular Surgery, RWTH Aachen University Hospital, Aachen, Germany., Bechter-Hugl B; Department of Vascular Surgery, Centre for Lymphedema, UZ Leuven - University Hospitals Leuven, Leuven, Belgium., Thomis S; Department of Vascular Surgery, Centre for Lymphedema, UZ Leuven - University Hospitals Leuven, Leuven, Belgium., Hermanns-Sachweh B; Implant Pathology, ZBMT, Campus Melaten, Aachen, Germany., Coudyzer W; Department of Radiology, UZ Leuven - University Hospitals Leuven, Leuven, Belgium., Yan Y; Clinic of Vascular and Endovascular Surgery, RWTH Aachen University Hospital, Aachen, Germany., Shekarchian S; Department of Vascular Surgery, Maastricht University Medical Centre, Maastricht, the Netherlands., Jalaie H; Clinic of Vascular and Endovascular Surgery, RWTH Aachen University Hospital, Aachen, Germany.
Jazyk:	angličtina
Zdroj:	JVS-vascular science [JVS Vasc Sci] 2023 May 25; Vol. 4, pp. 100113. Date of Electronic Publication: 2023 May 25 (Print Publication: 2023).
DOI:	10.1016/j.jvssci.2023.100113
Abstrakt:	Objective: Our study was a prospective in vivo study performed on an animal model to evaluate the safety and performance of a novel venous stent designed specifically for venous applications. Methods: The novel stents were implanted in the inferior vena cava of nine sheep. The stents were deployed with different distances between the closed cell rings to test for if the segments might migrate after being deployed at maximal distance. Three different total lengths were 9, 11, and 13 cm. After 1, 3, and 6 months, vascular injury, thrombus, neointima coverage, and stent migration were evaluated through computed tomography venography and histopathology. Imaging, histology, and integration data were analyzed for each group. Results: All stents were deployed successfully, and all sheep survived until the time of harvesting. In all cases, the native blood vessel sections were intact. The segmented stent parts showed a differently pronounced tissue coverage, depending on the duration of the implantation. Conclusions: The new nitinol stent is safe and feasible to implant in the venous system with a rapid surface coverage. Alteration of stent length did not affect the development of neointimal formation and did not cause migration. (© 2023 by the Society for Vascular Surgery. Published by Elsevier Inc.)
Databáze:	MEDLINE
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