PreCancer Atlas: Present and Future.
| Autor: | Srivastava S; Division of Cancer Prevention, National Cancer Institute, NIH, Rockville, Maryland., Wagner PD; Division of Cancer Prevention, National Cancer Institute, NIH, Rockville, Maryland., Hughes SK; Division of Cancer Biology, National Cancer Institute, NIH, Rockville, Maryland., Ghosh S; Division of Cancer Biology, National Cancer Institute, NIH, Rockville, Maryland. |
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| Jazyk: | angličtina |
| Zdroj: | Cancer prevention research (Philadelphia, Pa.) [Cancer Prev Res (Phila)] 2023 Jul 05; Vol. 16 (7), pp. 379-384. |
| DOI: | 10.1158/1940-6207.CAPR-22-0435 |
| Abstrakt: | Precancer atlases have the potential to revolutionize how we think about the topographic and morphologic structures of precancerous lesions in relation to cellular, molecular, genetic, and pathophysiologic states. This mini review uses the Human Tumor Atlas Network (HTAN), established by the National Cancer Institute (NCI), to illustrate the construction of cellular and molecular three-dimensional atlases of human cancers as they evolve from precancerous lesions to advanced disease. We describe the collaborative nature of the network and the research to determine how and when premalignant lesions progress to invasive cancer, regress or obtain a state of equilibrium. We have attempted to highlight progress made by HTAN in building precancer atlases and discuss possible future directions. It is hoped that the lessons from our experience with HTAN will help other investigators engaged in the construction of precancer atlases to crystallize their thoughts on logistics, rationale, and implementation. (©2023 American Association for Cancer Research.) |
| Databáze: | MEDLINE |
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