Circumstances, causes and timing of death in extremely preterm infants admitted to NICU: The EPIPAGE-2 study.

Autor: Boileau P; Department of Neonatal Pediatrics, Poissy Saint Germain Hospital, Versailles Saint Quentin en Yvelines University, Poissy, France., Letouzey M; Department of Neonatal Pediatrics, Poissy Saint Germain Hospital, Versailles Saint Quentin en Yvelines University, Poissy, France.; Université Paris Cité, Sorbonne Paris-Nord, Inserm, INRAE, CRESS, Obstetrical Perinatal and Pediatric Epidemiology Research Team, Université Paris Cité, Paris, France., Morgan AS; Université Paris Cité, Sorbonne Paris-Nord, Inserm, INRAE, CRESS, Obstetrical Perinatal and Pediatric Epidemiology Research Team, Université Paris Cité, Paris, France.; Department of Neonatology, North Hospital, Assistance Publique des Hôpitaux de Marseille, Marseille, France.; Elizabeth Garrett Anderson Institute for Women's Health London, University College London, London, UK., Lorthe E; Université Paris Cité, Sorbonne Paris-Nord, Inserm, INRAE, CRESS, Obstetrical Perinatal and Pediatric Epidemiology Research Team, Université Paris Cité, Paris, France.; Unit of Population Epidemiology, Department of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland., Kaminski M; Université Paris Cité, Sorbonne Paris-Nord, Inserm, INRAE, CRESS, Obstetrical Perinatal and Pediatric Epidemiology Research Team, Université Paris Cité, Paris, France., Coquelin A; Université Paris Cité, Sorbonne Paris-Nord, Inserm, INRAE, CRESS, Obstetrical Perinatal and Pediatric Epidemiology Research Team, Université Paris Cité, Paris, France., Azria E; Université Paris Cité, Sorbonne Paris-Nord, Inserm, INRAE, CRESS, Obstetrical Perinatal and Pediatric Epidemiology Research Team, Université Paris Cité, Paris, France.; Department of Obstetrics, Saint-Joseph Hospital, Paris, France., Caeymaex L; Department of Neonatal Pediatrics and Intensive Care, CHI, CRC, Créteil, France., Rouget F; Department of Neonatal Pediatrics, University Hospital Rennes, Rennes, France., Diguisto C; Université Paris Cité, Sorbonne Paris-Nord, Inserm, INRAE, CRESS, Obstetrical Perinatal and Pediatric Epidemiology Research Team, Université Paris Cité, Paris, France.; Department of Gynecology and Obstetrics, University hospital Tours, Tours, France., Claris O; Hospices Civils de Lyon, Department of Neonatology, Claude Bernard University, Lyon, France., Tosello B; Department of Neonatology, North Hospital, Assistance Publique des Hôpitaux de Marseille, Marseille, France.; Aix-Marseille Univ, CNRS, EFS, ADES, Marseille, France., Truffert P; Department of Neonatal Medicine, Jeanne de Flandre Hospital, CHRU Lille, Lille, France., Bétrémieux P; Department of Neonatal Pediatrics, University Hospital Rennes, Rennes, France., Benhammou V; Université Paris Cité, Sorbonne Paris-Nord, Inserm, INRAE, CRESS, Obstetrical Perinatal and Pediatric Epidemiology Research Team, Université Paris Cité, Paris, France., Marchand-Martin L; Université Paris Cité, Sorbonne Paris-Nord, Inserm, INRAE, CRESS, Obstetrical Perinatal and Pediatric Epidemiology Research Team, Université Paris Cité, Paris, France., Goffinet F; Université Paris Cité, Sorbonne Paris-Nord, Inserm, INRAE, CRESS, Obstetrical Perinatal and Pediatric Epidemiology Research Team, Université Paris Cité, Paris, France.; Department of Gynecology and Obstetrics, Port-Royal Hospital, APHP, Paris, France., Ancel PY; Université Paris Cité, Sorbonne Paris-Nord, Inserm, INRAE, CRESS, Obstetrical Perinatal and Pediatric Epidemiology Research Team, Université Paris Cité, Paris, France.; Center for Clinical Investigation P1419, APHP, APHP Centre-Université Paris Cité, Paris, France., Foix-L'Hélias L; Université Paris Cité, Sorbonne Paris-Nord, Inserm, INRAE, CRESS, Obstetrical Perinatal and Pediatric Epidemiology Research Team, Université Paris Cité, Paris, France.; Department of Neonatal Pediatrics, Trousseau Hospital, APHP, Sorbonne Université, Paris, France.
Jazyk: angličtina
Zdroj: Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] 2023 Oct; Vol. 112 (10), pp. 2066-2074. Date of Electronic Publication: 2023 Jul 12.
DOI: 10.1111/apa.16894
Abstrakt: Aim: To describe the circumstances, causes and timing of death in extremely preterm infants.
Methods: We included from the EPIPAGE-2 study infants born at 24-26 weeks in 2011 admitted to neonatal intensive care units (NICU). Vital status and circumstances of death were used to define three groups of infants: alive at discharge, death with or without withholding or withdrawing life-sustaining treatment (WWLST). The main cause of death was classified as respiratory disease, necrotizing enterocolitis, infection, central nervous system (CNS) injury, other or unknown.
Results: Among 768 infants admitted to NICU, 224 died among which 89 died without WWLST and 135 with WWLST. The main causes of death were respiratory disease (38%), CNS injury (30%) and infection (12%). Among the infants who died with WWLST, CNS injury was the main cause of death (47%), whereas respiratory disease (56%) and infection (20%) were the main causes in case of death without WWLST. Half (51%) of all deaths occurred within the first 7 days of life, and 35% occurred within 8 and 28 days.
Conclusion: The death of extremely preterm infants in NICU is a complex phenomenon in which the circumstances and causes of death are intertwined.
(© 2023 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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