A mix of aminophylline and heparin plus nitroglycerin can reduce bradycardia during rotational atherectomy on the right coronary artery and dominant circumflex artery.

Autor: Acar E; Faculty of Medicine, Department of Cardiology, Abant Izzet Baysal University, Bolu, Turkey. dreacar44@hotmail.com., Izci S; Kartal Koşuyolu Heart and Vascular Disease Research and Training Hospital, Istanbul, Turkey., Donmez I; Faculty of Medicine, Department of Cardiology, Abant Izzet Baysal University, Bolu, Turkey., Ozgul N; Cardiology Department, Kastamonu Training and Research Hospital, Kastamonu, Turkey., Ozcan E; Faculty of Medicine, Department of Cardiology, Abant Izzet Baysal University, Bolu, Turkey., Kaygusuz T; Faculty of Medicine, Department of Cardiology, Abant Izzet Baysal University, Bolu, Turkey., Kayabası O; Cardiology Department, Cankiri State Hospital, Cankırı, Turkey., Güneş Y; Faculty of Medicine, Department of Cardiology, Abant Izzet Baysal University, Bolu, Turkey., Izgi IA; Faculty of Medicine, Department of Cardiology, Abant Izzet Baysal University, Bolu, Turkey., Kirma C; Kartal Koşuyolu Heart and Vascular Disease Research and Training Hospital, Istanbul, Turkey.
Jazyk: angličtina
Zdroj: Herz [Herz] 2023 Dec; Vol. 48 (6), pp. 480-486. Date of Electronic Publication: 2023 Jul 04.
DOI: 10.1007/s00059-023-05195-1
Abstrakt: Background: Rotational atherectomy (RA) may cause bradyarrhythmias and transitory atrioventricular block when performed in the right coronary artery (RCA) or a dominant circumflex (CX) coronary artery. However, there are no studies of a solution that can prevent coronary flow deterioration and bradycardia complications that may occur during RA. We aimed to create an alternative rota-flush solution to minimize the risk of bradycardia and complete atrioventricular block (AVB) that can occur during RA.
Materials and Methods: The study comprised 60 patients who were randomly divided into two groups: 30 received rotaphylline (= 240 mg aminophylline, 10,000 U unfractionated heparin, and 2000 mcg nitroglycerin to 1000 mL saline), and 30 received the traditional rota-flush (= 10,000 U unfractionated heparin, 2000 mcg nitroglycerin, and 1000 mL saline). The incidence of bradycardia or high-grade AVB (HAVB) during RA, coronary slow-flow phenomenon or no-reflow phenomenon, and coronary spasm were the primary endpoints of the study. Procedure success and RA-related procedural complications were secondary endpoints.
Results: The use of rotaphylline was an independent predictor of bradycardia and HAVB after accounting for all other factors (OR: 0.47, 95% CI: 0.24-0.79, p < 0.001). Lesion length (OR: 2.17, 95% CI: 1.24-3.04, p < 0.001), burr-to-artery ratio (OR: 0.59, 95% CI: 0.39-1.68, p < 0.001), and total run duration (OR: 0.79, 95% CI: 0.35-1.43, p < 0.001) were additional independent predictors.
Conclusion: Bradycardia and the development of HAVB may be avoided by rotaphylline intracoronary infusion during RA applied to the RCA and dominant CX lesions. Multicenter studies including sizable patient populations should be conducted to validate the present findings.
(© 2023. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
Databáze: MEDLINE
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