Case report: Microangiopathic hemolytic anemia and thrombocytopenia in a child with Brucella infection.

Autor:	Alkhunein A; Department of Pediatrics, King Abdullah Specialist Children Hospital, Ministry of National Guard-Health Affairs (NGHA), Riyadh, Saudi Arabia.; King Abdullah International Medical Research Centre, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs (NGHA), Riyadh, Saudi Arabia., Albraikan A; Department of Pediatrics, King Abdullah Specialist Children Hospital, Ministry of National Guard-Health Affairs (NGHA), Riyadh, Saudi Arabia.; King Abdullah International Medical Research Centre, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs (NGHA), Riyadh, Saudi Arabia., Alayed M; Department of Pediatrics, King Abdullah Specialist Children Hospital, Ministry of National Guard-Health Affairs (NGHA), Riyadh, Saudi Arabia.; King Abdullah International Medical Research Centre, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs (NGHA), Riyadh, Saudi Arabia., Althaqafi W; Department of Pediatrics, King Abdullah Specialist Children Hospital, Ministry of National Guard-Health Affairs (NGHA), Riyadh, Saudi Arabia.; King Abdullah International Medical Research Centre, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs (NGHA), Riyadh, Saudi Arabia., Alharbi M; King Abdullah International Medical Research Centre, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs (NGHA), Riyadh, Saudi Arabia.; College of Medicine, King Saud bin Abdul-Aziz University for Health Science, Ministry of National Guard-Health Affairs (NGHA), Riyadh, Saudi Arabia.; Department of Pediatric Infectious Diseases, King Abdullah Specialist Children Hospital, Ministry of National Guard Health Affairs (NGHA), Riyadh, Saudi Arabia.
Jazyk:	angličtina
Zdroj:	Frontiers in pediatrics [Front Pediatr] 2023 Jun 15; Vol. 11, pp. 1139622. Date of Electronic Publication: 2023 Jun 15 (Print Publication: 2023).
DOI:	10.3389/fped.2023.1139622
Abstrakt:	Thrombotic thrombocytopenic purpura (TTP) is a diffused microvascular occlusive disorder characterized by microangiopathic hemolytic anemia (MAHA), thrombocytopenia, and ischemic organ dysfunction. In addition, this condition has been linked to an absence or dysfunction of ADAMTS13. Although TTP can occur due to various factors, such as bacteria, viruses, autoimmune disorders, drugs, connective tissue conditions, and solid tumors, it is a rare hematological complication associated with brucellosis. We describe the first case of a 9-year-old boy with acquired TTP with undetectable ADAMTS-13 assay secondary to Brucella infection. After initiating antimicrobial therapy, symptoms and laboratory abnormalities improved dramatically, with no recurrence of TTP in subsequent follow-ups. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (© 2023 Alkhunein, Albraikan, Alayed, Althaqafi and Alharbi.)
Databáze:	MEDLINE
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