Circulating biomarkers of cardiovascular disease are related to aneurysm volume in abdominal aortic aneurysm.
| Autor: | Bouwens E; Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands.; Department of Vascular Surgery, Erasmus MC, Rotterdam, The Netherlands.; Department of Anesthesiology, Erasmus MC, Rotterdam, The Netherlands., Vanmaele A; Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands.; Department of Vascular Surgery, Erasmus MC, Rotterdam, The Netherlands., Hoeks SE; Department of Anesthesiology, Erasmus MC, Rotterdam, The Netherlands., Verhagen HJ; Department of Vascular Surgery, Erasmus MC, Rotterdam, The Netherlands., Fioole B; Department of Vascular Surgery, Maasstad Hospital, Rotterdam, The Netherlands., Moelker A; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands., Ten Raa S; Department of Vascular Surgery, Erasmus MC, Rotterdam, The Netherlands., Hussain B; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.; Department of Radiology, Beatrix Hospital, Gorinchem, The Netherlands., Oliveira-Pinto J; Department of Vascular Surgery, Erasmus MC, Rotterdam, The Netherlands.; Department of Angiology and Vascular Surgery, Centro Hospitalar São João, Porto, Portugal.; Department of Surgery and Physiology, Faculty of Medicine of Oporto, Porto, Portugal., Bastos Gonçalves F; Department of Vascular Surgery, Erasmus MC, Rotterdam, The Netherlands.; NOVA Medical School, Universidade NOVA de Lisboa, Lisbon, Portugal.; Department of Angiology and Vascular Surgery, Hospital de Santa Marta, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal., Ijpma AS; Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands., Hoefer IE; Central Diagnostic Laboratory, University Medical Center Utrecht, Utrecht, The Netherlands., van Lier F; Department of Anesthesiology, Erasmus MC, Rotterdam, The Netherlands., Akkerhuis KM; Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands., Majoor-Krakauer DF; Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands., Boersma E; Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands., Kardys I; Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands. |
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| Jazyk: | angličtina |
| Zdroj: | Vascular medicine (London, England) [Vasc Med] 2023 Oct; Vol. 28 (5), pp. 433-442. Date of Electronic Publication: 2023 Jul 03. |
| DOI: | 10.1177/1358863X231181159 |
| Abstrakt: | Background: Surveillance programs in abdominal aortic aneurysms (AAA) are mainly based on imaging and leave room for improvement to timely identify patients at risk for AAA growth. Many biomarkers are dysregulated in patients with AAA, which fuels interest in biomarkers as indicators of disease progression. We examined associations of 92 cardiovascular disease (CVD)-related circulating biomarkers with AAA and sac volume. Methods: In a cross-sectional analysis, we separately investigated (1) 110 watchful waiting (WW) patients (undergoing periodic surveillance imaging without planned intervention) and (2) 203 patients after endovascular aneurysm repair (EVAR). The Cardiovascular Panel III (Olink Proteomics AB, Sweden) was used to measure 92 CVD-related circulating biomarkers. We used cluster analyses to investigate protein-based subphenotypes, and linear regression to examine associations of biomarkers with AAA and sac volume on CT scans. Results: Cluster analyses revealed two biomarker-based subgroups in both WW and EVAR patients, with higher levels of 76 and 74 proteins, respectively, in one subgroup versus the other. In WW patients, uPA showed a borderline significant association with AAA volume. Adjusting for clinical characteristics, there was a difference of -0.092 (-0.148, -0.036) log Conclusion: LDLR, TFPI, TIMP4, and IGFBP-2 were independently associated with sac volume after EVAR. Subgroups of patients with high levels of the majority of CVD-related biomarkers emphasize the intertwined relationship between AAA and CVD. ClinicalTrials.gov Identifier: NCT03703947. Competing Interests: Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| Databáze: | MEDLINE |
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