Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data.

Autor:	Cannarella R; Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.; Glickman Urological & Kidney Institute, Cleveland Clinic Foundation, Cleveland, OH, USA., Shah R; Department of Urology, Lilavati Hospital and Research Centre, Mumbai, India., Hamoda TAA; Department of Urology, King Abdulaziz University, Jeddah, Saudi Arabia.; Department of Urology, Faculty of Medicine, Minia University, Minia, Egypt., Boitrelle F; Department of Reproductive Biology, Fertility Preservation, Andrology, CECOS, Poissy Hospital, Poissy, France.; Department of Biology, Reproduction, Epigenetics, Environment and Development, Paris Saclay University, UVSQ, INRAE, BREED, Jouy-en-Josas, France., Saleh R; Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University, Sohag, Egypt., Gul M; Department of Urology, Selcuk University School of Medicine, Konya, Turkey., Rambhatla A; Department of Urology, Henry Ford Health System, Vattikuti Urology Institute, Detroit, MI, USA., Kavoussi P; Department of Reproductive Urology, Austin Fertility & Reproductive Medicine/Westlake IVF, Austin, TX, USA., Toprak T; Department of Urology, Fatih Sultan Mehmet Training and Research Hospital, University of Health Sciences, Istanbul, Turkey., Harraz AM; Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.; Department of Surgery, Urology Unit, Farwaniya Hospital, Farwaniya, Kuwait.; Department of Urology, Sabah Al Ahmad Urology Center, Kuwait City, Kuwait., Ko E; Department of Urology, Loma Linda University Health, Loma Linda, CA, USA., Çeker G; Department of Urology, Başakşehir Cam and Sakura City Hospital, Istanbul, Turkey., Durairajanayagam D; Department of Physiology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Selangor, Malaysia., Alkahidi N; Department of Internal Medicine, Trinity Health/Mercy Health, Muskegon, MI, USA., Kuroda S; Glickman Urological & Kidney Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.; Department of Urology, Reproduction Center, Yokohama City University Medical Center, Yokohama, Japan., Crafa A; Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy., Henkel R; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Medical Bioscience, University of the Western Cape, Bellville, South Africa., Salvio G; Department of Endocrinology, Polytechnic University of Marche, Ancona, Italy., Hazir B; Reproductive Medicine, Clinical Research Centre, Lund University, Malmö, Sweden., Darbandi M; Fetal Health Research Center, Hope Generation Foundation, Tehran, Iran.; Gene Therapy and Regenerative Medicine Research Center, Hope Generation Foundation, Tehran, Iran., Bendayan M; Department of Reproductive Biology, Fertility Preservation, Andrology, CECOS, Poissy Hospital, Poissy, France.; Department of Biology, Reproduction, Epigenetics, Environment and Development, Paris Saclay University, UVSQ, INRAE, BREED, Jouy-en-Josas, France., Darbandi S; Fetal Health Research Center, Hope Generation Foundation, Tehran, Iran.; Gene Therapy and Regenerative Medicine Research Center, Hope Generation Foundation, Tehran, Iran., Falcone M; Department of Urology, Molinette Hospital, A.O.U. Città della Salute e della Scienza, University of Turin, Torino, Italy., Garrido N; IVIRMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, Spain., Kosgi R; Department of Urology, Andrology and Renal Transplant, AIG Hospitals, Hyderabad, India., Sawaid Kaiyal R; Glickman Urological & Kidney Institute, Cleveland Clinic Foundation, Cleveland, OH, USA., Karna K; Department of Molecular Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA., Phuoc NHV; Department of Andrology, Binh Dan Hospital, Ho Chi Minh, Vietnam.; Department of Urology and Andrology, Pham Ngoc Thach University of Medicine, Ho Chi Minh, Vietnam., Birowo P; Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia., Colpi GM; Andrology and IVF Center, Next Fertility Procrea, Lugano, Switzerland., de la Rosette J; Department of Urology, Istanbul Medipol Mega University Hospital, Istanbul, Turkey., Pinggera GM; Department of Urology, Innsbruck Medical University, Innsbruck, Austria., Nguyen Q; Center for Andrology and Sexual Medicine, Viet Duc University Hospital, Hanoi, Vietnam.; Department of Urology, Andrology and Sexual Medicine, University of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam., Zini A; Division of Urology, Department of Surgery, McGill University, Montreal, QC, Canada., Zohdy W; Department of Andrology, Sexology & STIs, Faculty of Medicine, Cairo University, Cairo, Egypt., Singh R; Central Drug Research Institute, Male Reproductive Health Research Laboratory, Lucknow, Uttar Pradesh, India., Saini P; Division of Endocrinology, Central Drug Research Institute, Lucknow, India., Glina S; Division of Urology, Centro Universitario FMABC, Santo André, Brazil., Lin H; Department of Urology, Peking University Third Hospital, Peking University, Beijing, China., Mostafa T; Department of Andrology, Sexology & STIs, Faculty of Medicine, Cairo University, Cairo, Egypt., Rojas-Cruz C; Department of Urology, University Hospital of Rostock, Rostock, Germany., Arafa M; Department of Andrology, Sexology & STIs, Faculty of Medicine, Cairo University, Cairo, Egypt.; American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.; Department of Urology, Hamad Medical Corporation, Doha, Qatar.; Department of Urology, Weill Cornell Medical-Qatar, Doha, Qatar., Calogero AE; Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy., Dimitriadis F; Department of Urology, Aristotle University School of Medicine, Thessaloniki, Greece., Kothari P; Department of Urology, Topiwala National Medical College, B.Y.L Nair Ch Hospital, Mumbai, India., Karthikeyan VS; Andrology Unit, Department of Urology, Apollo Hospitals, Greams Road, Chennai, India., Okada K; Department of Urology, Kobe University Graduate School of Medicine, Kobe, Japan., Chiba K; Department of Urology, Kobe University Graduate School of Medicine, Kobe, Japan., Kadıoglu A; Department of Urology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey., Altay B; Department of Urology, Ege University, Izmir, Turkey., Turunc T; Urocentre Urology Clinic, Adana, Turkey., Zilaitiene B; Institute of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania, Turkey., Gokalp F; Department of Urology, Faculty of Medicine, Hatay Mustafa Kemal University, Antakya, Hatay, Turkey., Adamyan A; Department of Urology, Astghik Medical Center, Yerevan, Armenia., Katz D; Men's Health Melbourne, Victoria, Australia.; Department of Surgery, Western Precinct, University of Melbourne, Victoria, Australia.; Department of Urology, Western Health, Victoria, Australia., Chung E; Department of Urology, Princess Alexandra Hospital, University of Queensland, Brisbane, Australia., Mierzwa TC; Division of Urology, Centro Universitario FMABC, Santo André, Brazil., Zylbersztejn DS; Fleury Group and Hospital Israelita Albert Einstein, São Paulo, Brazil., Paul GM; Department of Clinical Surgery, Health Sciences Sector of the Federal University of Parana (UFPR), Curitiba, Paraná, Brazil., Sofikitis N; Department of Urology, Ioannina University School of Medicine, Ioannina, Greece., Sokolakis I; 2nd Department of Urology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece., Malhotra V; SCM Clinic and Hospital, New Delhi, India., Brodjonegoro SR; Division of Urology, Department of Surgery, Prof. Dr. Sardjito Hospital, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia., Adriansjah R; Department of Urology, Hasan Sadikin Hospital, Medical Faculty of Padjadjaran University, Bandung, Indonesia., Tsujimura A; Department of Urology, Juntendo University Urayasu Hospital, Chiba, Japan., Amano T; Department of Urology, Nagano Red Cross Hospital, Nagano, Japan., Balercia G; Department of Endocrinology, Polytechnic University of Marche, Ancona, Italy., Ziouziou I; Department of Urology, College of Medicine and Pharmacy, Ibn Zohr University, Agadir, Morocco., Deswanto IA; Elang Medika Corpora Hospital, Tangerang, Indonesia., Martinez M; Section of Urology, Department of Surgery, University of Santo Tomas Hospital, Manila, Philippines., Park HJ; Department of Urology, Pusan National University School of Medicine, Busan, Korea.; Medical Research Institute of Pusan National University Hospital, Busan, Korea., Bakırcıoglu ME; SENSART Clinic, Istanbul, Turkey., Ceyhan E; Department of Urology, Baskent University Faculty of Medicine, Ankara, Turkey., Aydos K; Department of Urology, Ankara University School of Medicine, Ankara, Turkey., Ramsay J; Department of Andrology, Hammersmith Hospital, Imperial, London, UK., Minhas S; Department of Urology, Imperial Healthcare NHS Trust, Charing Cross Hospital, London, UK., Al Hashimi M; Department of Urology, Burjeel Hospital, Abu Dhabi, UAE.; Clinical Urology, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi, UAE., Ghayda RA; Institute of Urology, University Hospitals, Case Western Reserve University, Cleveland, OH, USA., Tadros N; Division of Urology, Southern Illinois University School of Medicine, Springfield, IL, USA., Sindhwani P; Department of Urology, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA., Ho CCK; Department of Surgery, School of Medicine, Taylor's University, Subang Jaya, Selangor, Malaysia., Rachman RI; Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia., Rodriguez Pena M; Instituto de Ginecología y Fertilidad (IFER) y Universidad Barcelo, Buenos Aires, Argentina., Motawi A; Department of Andrology, Sexology & STIs, Faculty of Medicine, Cairo University, Cairo, Egypt., Ponnusamy AK; AndroOne Men's Health Clinic, Salem, India., Dipankar S; Department of Physiology, All India Institute of Medical Sciences Mangalagiri, Mangalagiri, India., Amir A; Department of Urology, Dr Wahidin Sudirohusodo Hospital, Makassar, Indonesia., Binsaleh S; Division of Urology, Department of Surgery, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia., Serefoglu EC; Department of Urology, Biruni University School of Medicine, Istanbul, Turkey., Banthia R; Department of Urology, Western General Hospital, Edinburgh, UK., Khalafalla K; Department of Urology, Hamad Medical Corporation, Doha, Qatar.; Urology Department, University of Texas McGovern Medical School, Houston, TX, USA.; Department of Urology, MD Anderson Cancer Center, Houston, TX, USA., Basukarno A; Department of Urology, Dr. Dradjat Hospital, Serang, Indonesia., Bac NH; Department of Andrology and Sexual Medicine, Hanoi Medical University's Hospital, Hanoi, Vietnam., Singla K; Clarity Health, Chandigarh, India., Ambar RF; Division of Urology, Centro Universitario FMABC, Santo André, Brazil.; Andrology Department at Ideia Fertil Institute, Santo Andre, São Paulo, Brazil., Makarounis K; Department of Urology and Andrology, Locus Medicus, Athens, Greece., Priyadarshi S; Department of Urology, Sawai Man Singh Medical College and Hospital, Jaipur, Rajasthan, India., Duarsa GWK; Department of Urology, Prof. Dr. I.G.N.G Ngoerah General Hospital, Faculty of Medicine, Universitas Udayana, Bali, Indonesia., Atmoko W; Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia., Jindal S; Department of Andrology & Reproductive Medicine, Jindal Hospital & Fertility Center, Meerut, India., Arianto E; Department of Urology, Prof R.D. Kandou Hospital, Manado, Indonesia., Akhavizadegan H; Urology Department, Tehran University of Medical Scienes, Tehran, Iran., El Bardisi H; Department of Urology, Hamad Medical Corporation, Doha, Qatar.; Department of Urology, Weill Cornell Medical-Qatar, Doha, Qatar., Shoshany O; Department of Urology, University of Illinois at Chicago, Chicago, IL, USA., Busetto GM; Department of Urology and Renal Transplantation, Univeristy of Foggia, Foggia, Italy., Moussa M; Department of Urology, Lebanese University, Beirut, Lebanon., Jamali M; Department of Urology, Military Teaching Hospital, Rabat, Morocco., Al-Marhoon MS; Department of Surgery, Urology Division, Sultan Qaboos University, Muscat, Oman., Ruzaev M; Urology Clinic, Moscow, Russia., Farsi HMA; Department of Urology, King Abdulaziz University, Jeddah, Saudi Arabia., Mutambirwa S; Department of Urology, Dr. George Mukhari Academic Hospital, Sefako Makgatho Health Science University, Medunsa, Ga-Rankuwa, South Africa., Lee DS; Department of Urology, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea., Kulaksiz D; Department of Obstetrics and Gynecology, University of Health Sciences, Kanuni Training and Research Hospital, Trabzon, Turkey., Cheng YS; Department of Urology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan., Bouzouita A; Department of Anatomy, Faculty of Medicine, Faculty Tunis Manar, Tunis, Tunisia., Sarikaya S; Department of Urology, Gulhane Research and Training Hospital, University of Health Sciences, Ankara, Turkey., Kandil H; Fakih IVF Fertility Center, Abu Dhabi, UAE., Tsampoukas G; Department of Urology, Oxford University Hospital, Oxford, UK., Farkouh A; Global Andrology Forum, Moreland Hills, OH, USA., Bowa K; Department of Urology, School of Medicine and Health Sciences, University of Lusaka, Lusaka, Zambia., Savira M; Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia., Mogharabian N; Sexual Health and Fertility Research Center, Shahroud University of Medical Sciences, Shahroud, Iran., Le TV; Department of Andrology, Binh Dan Hospital, Ho Chi Minh, Vietnam.; Department of Urology and Andrology, Pham Ngoc Thach University of Medicine, Ho Chi Minh, Vietnam., Harjanggi M; IVF Jakarta - YPK Mandiri, Jakarta, Indonesia., Anh DT; Tam Anh IVF Center, Tam Anh General Hospital, Hanoi, Vietnam., Long TQT; Department of Obstetrics and Gynecology, Hanoi Obstetric and Gynecology Hospital, Hanoi, Vietnam., Soebadi MA; Department of Urology, Soetomo Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia., Hakim L; Department of Urology, Universitas Airlangga Teaching Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia., Tanic M; Department of Urology, General Hospital, Cuprija, Serbia., Ari UC; Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Kafkas University, Kars, Turkey., Parikh FR; FertilTree-Jaslok International Fertility Centre, Jaslok Hospital, Mumbai, Maharashtra, India., Calik G; Department of Urology, Istanbul Medipol Mega University Hospital, Istanbul, Turkey., Kv V; Cure & SK Hospital, Trivandrum, India., Dorji G; Department of Anatomy, Khesar Gyalpo University of Medical Sciences of Bhutan, Thimphu, Bhutan., Rezano A; Andrology Study Program, Department of Biomedical Sciences, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia.; Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java, Indonesia., Rajmil O; Department of Andrology, Fundacio Puigvert, Barcelona, Spain., Tien DMB; Department of Andrology, Binh Dan Hospital, Ho Chi Minh, Vietnam., Yuan Y; Department of Urology, Peking University Third Hospital, Peking University, Beijing, China., Lizarraga-Salas JF; Instituto de Ciencias en Reproducción Humana Vida, León, Mexico., Eze B; Department of Surgery, College of Medicine, Enugu State University of Science and Technology, Enugu, Nigeria., Ngoo KS; Urology Unit, Department of Surgery, Hospital Angkatan Tentera Tuanku Mizan, Kuala Lumpur, Malaysia., Lee J; Department of Urology, National University Hospital, Singapore., Arslan U; Department of Urology, Fatih Sultan Mehmet Training and Research Hospital, University of Health Sciences, Istanbul, Turkey., Agarwal A; Department of Urology, School of Medicine and Health Sciences, University of Lusaka, Lusaka, Zambia.; Cleveland Clinic, Cleveland, OH, USA. Agarwal@globalandrology.org.
Jazyk:	angličtina
Zdroj:	The world journal of men's health [World J Mens Health] 2024 Jan; Vol. 42 (1), pp. 92-132. Date of Electronic Publication: 2023 Jun 22.
DOI:	10.5534/wjmh.230034
Abstrakt:	Purpose: The purpose of this meta-analysis is to study the impact of varicocele repair in the largest cohort of infertile males with clinical varicocele by including all available studies, with no language restrictions, comparing intra-person conventional semen parameters before and after the repair of varicoceles. Materials and Methods: The meta-analysis was performed according to PRISMA-P and MOOSE guidelines. A systematic search was performed in Scopus, PubMed, Cochrane, and Embase databases. Eligible studies were selected according to the PICOS model (Population: infertile male patients with clinical varicocele; Intervention: varicocele repair; Comparison: intra-person before-after varicocele repair; Outcome: conventional semen parameters; Study type: randomized controlled trials [RCTs], observational and case-control studies). Results: Out of 1,632 screened abstracts, 351 articles (23 RCTs, 292 observational, and 36 case-control studies) were included in the quantitative analysis. The before-and-after analysis showed significant improvements in all semen parameters after varicocele repair (except sperm vitality); semen volume: standardized mean difference (SMD) 0.203, 95% CI: 0.129-0.278; p<0.001; I²=83.62%, Egger's p=0.3329; sperm concentration: SMD 1.590, 95% CI: 1.474-1.706; p<0.001; I²=97.86%, Egger's p<0.0001; total sperm count: SMD 1.824, 95% CI: 1.526-2.121; p<0.001; I²=97.88%, Egger's p=0.0063; total motile sperm count: SMD 1.643, 95% CI: 1.318-1.968; p<0.001; I²=98.65%, Egger's p=0.0003; progressive sperm motility: SMD 1.845, 95% CI: 1.537%-2.153%; p<0.001; I²=98.97%, Egger's p<0.0001; total sperm motility: SMD 1.613, 95% CI 1.467%-1.759%; p<0.001; l2=97.98%, Egger's p<0.001; sperm morphology: SMD 1.066, 95% CI 0.992%-1.211%; p<0.001; I²=97.87%, Egger's p=0.1864. Conclusions: The current meta-analysis is the largest to date using paired analysis on varicocele patients. In the current meta-analysis, almost all conventional semen parameters improved significantly following varicocele repair in infertile patients with clinical varicocele. Competing Interests: The authors have nothing to disclose. (Copyright © 2024 Korean Society for Sexual Medicine and Andrology.)
Databáze:	MEDLINE
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