The factors predicting development of serious infections in ANCA-associated vasculitis.

Autor:	Uslu Yurteri E; Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey. drusluemine@gmail.com., Sezer S; Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey. serdarsezer1987@hotmail.com., Torgutalp M; Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey; Department of Gastroenterology, Infectiology and Rheumatology, Charite Universitatsmedizin Berlin Campus Benjamin Franklin, Berlin, Germany. mtorgutalp@gmail.com., Yayla ME; Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey. enesyayla@hotmail.com., Sahin Eroglu D; Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey. dr.didemsa@gmail.com., Okatan IE; Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey. ilyas.okatan@gmail.com., Kelesoglu Dincer AB; Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey. abaharkelesoglu@hotmail.com., Aydemir Guloksuz EG; Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey. gzd_aydemir@hotmail.com., Yuksel ML; Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey. Leventyuksel_52@hotmail.com., Turgay TM; Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey. tmturgay@hotmail.com., Ates A; Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey. askinates1970@hotmail.com., Kinikli G; Department of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey. gkinikli@gmail.com.
Jazyk:	angličtina
Zdroj:	Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG [Sarcoidosis Vasc Diffuse Lung Dis] 2023 Jun 29; Vol. 40 (2), pp. e2023015. Date of Electronic Publication: 2023 Jun 29.
DOI:	10.36141/svdld.v40i2.13243
Abstrakt:	Background: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare autoimmune disease usually involving small vessels and progressing with necrotizing inflammation. Treatment requires long-term use of immunosuppressive agents to inhibit disease activity. Serious infections (SIs) are a common complication in AAV. Objective: The aim of this study was to identify the risk factors for serious infections which required hospitalization in patients with AAV. Methods: In this retrospective cohort study., we included 84 patients admitted to the Ankara University Faculty of Medicine in the last 10 years with a diagnosis of AAV. Results: In 42 (50%) of 84 patients followed up with the diagnosis of AAV, an infection requiring hospitalization was identified. The patients' total corticosteroid dose, use of pulse steroids, induction regimen, levels of C-reactive protein (CRP) and the presence of pulmonary and renopulmonary involvement were found to be associated with the frequency of infection (p=0.015, p=0.016, p=0.010, p=0.03, p= 0.026 and p=0.029, respectively). In multivariable analysis, it was found that renopulmonary involvement (p=0.002, HR=4.95, 95% CI= 1.804-13.605), age of over 65 (p=0.049, HR=3.37, 95% CI=1.004-11.369) and high CRP levels (p=0.043, HR=1.006, 95% CI=1.000-1.011) constituted independent predictors of serious infection risk. Conclusion: The frequency of infection is known to be increased in ANCA-associated vasculitis. Our study showed that renopulmonary involvement, age and elevated CRP levels on admission are independent risk factors of infection.
Databáze:	MEDLINE
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