Functions, mechanisms, and clinical applications of lncRNA LINC00857 in cancer pathogenesis.

Autor: Aldayyeni H; Nottingham University Hospital, NHS Trust, Nottingham, UK., Hjazi A; Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia., Shahab S; Department of Business Administration, College of Business Administration, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia., Gupta J; Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, 281406, India., Alsaab HO; Department of Pharmaceutics and Pharmaceutical Technology, Taif University, Taif, 21944, Saudi Arabia., Motea YH; College of Dentistry, Al-Bayan University, Baghdad, Iraq., Alazbjee AAA; College of Medicine, Al-Ayen University, Thi-Qar, Nasiriyah, Iraq., Romero-Parra RM; Universidad Continental, Lima, Perú. rosarioromeroparra@gmail.com., Obaid RF; Department of Biomedical Engineering, Al-Mustaqbal University College, Babylon, Iraq., Hussien BM; Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq., Hosseini-Fard SR; Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Jazyk: angličtina
Zdroj: Human cell [Hum Cell] 2023 Sep; Vol. 36 (5), pp. 1656-1671. Date of Electronic Publication: 2023 Jun 28.
DOI: 10.1007/s13577-023-00936-0
Abstrakt: Emerging data indicated that long noncoding RNAs (lncRNAs) are crucial players in the biological processes via regulating epigenetics, transcription, and protein translation. A novel lncRNA, LINC00857, was indicated to upregulate in several types of cancer. In addition, LINC00857 was functionally related to the modulation of the cancer-linked behaviors, including invasion, migration, proliferation, epithelial-mesenchymal transition (EMT), cell cycle, and apoptosis. The importance of LINC00857 in cancer onset and development proposed that LINC00857 has major importance in the cancer progression and may be considered as a novel prognostic/diagnostic biomarker as well as a treatment target. Here, we retrospectively investigate the available progress in biomedical research investigating the functions of LINC00857 in cancer, focusing on finding the molecular mechanisms affecting various cancer-related behaviors and exploring its clinical applications.
(© 2023. The Author(s) under exclusive licence to Japan Human Cell Society.)
Databáze: MEDLINE
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