Electrospun Fibrous Silica for Bone Tissue Engineering Applications.

Autor: Stoica Oprea AE; Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania., Bîrcă AC; Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania., Gherasim O; Lasers Department, National Institute for Lasers, Plasma and Radiation Physics, 409 Atomistilor Street, 077125 Magurele, Romania., Ficai A; Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania., Grumezescu AM; Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania.; Research Institute of the University of Bucharest-ICUB, University of Bucharest, 050657 Bucharest, Romania.; Academy of Romanian Scientists, Ilfov No. 3, 050044 Bucharest, Romania., Oprea OC; Academy of Romanian Scientists, Ilfov No. 3, 050044 Bucharest, Romania.; Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Gheorghe Polizu Street, 011061 Bucharest, Romania., Vasile BȘ; National Research Center for Micro and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, Romania.; HTP Research and Consulting, Joita, 087150 Giurgiu, Romania.; Research Center for Advanced Materials, Products and Processes, University of Bucharest, 060042 Bucharest, Romania., Balta C; 'Aurel Ardelean' Institute of Life Sciences, Vasile Goldiş Western University of Arad, 310025 Arad, Romania., Andronescu E; Department of Science and Engineering of Oxide Materials and Nanomaterials, University Politehnica of Bucharest, 011061 Bucharest, Romania.; Academy of Romanian Scientists, Ilfov No. 3, 050044 Bucharest, Romania., Hermenean AO; 'Aurel Ardelean' Institute of Life Sciences, Vasile Goldiş Western University of Arad, 310025 Arad, Romania.
Jazyk: angličtina
Zdroj: Pharmaceutics [Pharmaceutics] 2023 Jun 14; Vol. 15 (6). Date of Electronic Publication: 2023 Jun 14.
DOI: 10.3390/pharmaceutics15061728
Abstrakt: The production of highly porous and three-dimensional (3D) scaffolds with biomimicking abilities has gained extensive attention in recent years for tissue engineering (TE) applications. Considering the attractive and versatile biomedical functionality of silica (SiO 2 ) nanomaterials, we propose herein the development and validation of SiO 2 -based 3D scaffolds for TE. This is the first report on the development of fibrous silica architectures, using tetraethyl orthosilicate (TEOS) and polyvinyl alcohol (PVA) during the self-assembly electrospinning (ES) processing (a layer of flat fibers must first be created in self-assembly electrospinning before fiber stacks can develop on the fiber mat). The compositional and microstructural characteristics of obtained fibrous materials were evaluated by complementary techniques, in both the pre-ES aging period and post-ES calcination. Then, in vivo evaluation confirmed their possible use as bioactive scaffolds in bone TE.
Databáze: MEDLINE
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