| Autor: |
Campos J; INEB-Instituto Nacional de Engenharia Biomédica, 4200-135 Porto, Portugal.; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal., Pires MF; Faculdade de Medicina Dentária, Universidade do Porto, 4200-393 Porto, Portugal., Sousa M; Faculdade de Medicina Dentária, Universidade do Porto, 4200-393 Porto, Portugal., Campos C; Instituto Português de Oncologia do Porto Francisco Gentil, 4200-072 Porto, Portugal.; Escola Superior de Saúde, Instituto Politécnico do Porto, 4200-072 Porto, Portugal., da Costa CFFA; INEB-Instituto Nacional de Engenharia Biomédica, 4200-135 Porto, Portugal.; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.; Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050-313 Porto, Portugal., Sampaio-Maia B; INEB-Instituto Nacional de Engenharia Biomédica, 4200-135 Porto, Portugal.; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.; Faculdade de Medicina Dentária, Universidade do Porto, 4200-393 Porto, Portugal. |
| Abstrakt: |
Staphylococcus aureus is both a human commensal and a pathogen, that causes serious nosocomial and community-acquired infections. Despite nostrils being considered its preferred host habitat, the oral cavity has been demonstrated to be an ideal starting point for auto-infection and transmission. The antibiotic resistance assessment of S. aureus is a priority and is often reported in clinical settings. This study aimed to explore the prevalence and antimicrobial susceptibility of S. aureus in the oral and nasal cavities of healthy individuals. The participants ( n = 101) were subjected to a demographic and clinical background survey, a caries evaluation, and to oral and nasal swabbing. Swabs were cultured in differential/selective media and S. aureus isolates were identified (MALDI-TOF MS) and tested for antibiotic susceptibility (EUCAST/CLSI). Similar S. aureus prevalence was found exclusively on nasal (13.9%) or oral (12.0%) habitats, whereas 9.9% of the population were simultaneous nasal and oral carriers. In oro-nasal cavities, similar antibiotic resistance rates (83.3-81.5%), including MDR (20.8-29.6%), were observed. Notably, 60% (6/10) of the simultaneous nasal and oral carriers exhibited different antibiotic resistance profiles between cavities. This study demonstrates the relevance of the oral cavity as an independent colonization site for S. aureus and as a potential source of antimicrobial resistance, a role which has been widely neglected so far. |
