Tobacco Smoking and Pack-Years Are Associated With Frailty Among People With HIV.

Autor:	Ruderman SA; University of Washington, Seattle, WA, USA., Odden MC; Stanford University, Stanford, CA., Webel AR; University of Washington, Seattle, WA, USA., Fitzpatrick AL; University of Washington, Seattle, WA, USA., Crane PK; University of Washington, Seattle, WA, USA., Nance RM; University of Washington, Seattle, WA, USA., Drumright LN; University of Washington, Seattle, WA, USA., Whitney BM; University of Washington, Seattle, WA, USA., Mixson LS; University of Washington, Seattle, WA, USA., Ma J; University of Washington, Seattle, WA, USA., Willig AL; University of Alabama at Birmingham, Birmingham, AL., Haidar L; University of Manitoba, Winnipeg, Manitoba, CA., Eltonsy S; University of Manitoba, Winnipeg, Manitoba, CA., Mayer KH; Harvard Medical School, Fenway Institute, Boston, MA, USA., O'Cleirigh C; Harvard Medical School, Fenway Institute, Boston, MA, USA., Cropsey KL; University of Alabama at Birmingham, Birmingham, AL., Eron JJ; University of North Carolina, Chapel Hill, NC., Napravnik S; University of North Carolina, Chapel Hill, NC., Greene M; University of California San Francisco, San Francisco, CA., McCaul M; Johns Hopkins University, Baltimore, MD., Chander G; University of Washington, Seattle, WA, USA., Cachay E; University of California San Diego, San Diego, CA., Lober WB; University of Washington, Seattle, WA, USA., Kritchevsky SB; Wake Forest University School of Medicine, Winston-Salem, NC., Austad S; University of Alabama at Birmingham, Birmingham, AL., Landay A; Rush University, Chicago, IL; and., Pandya C; Johns Hopkins University, Baltimore, MD., Cartujano-Barrera F; University of Rochester, Rochester, NY., Saag MS; University of Alabama at Birmingham, Birmingham, AL., Kamen C; University of Rochester, Rochester, NY., Hahn AW; University of Washington, Seattle, WA, USA., Kitahata MM; University of Washington, Seattle, WA, USA., Delaney JAC; University of Manitoba, Winnipeg, Manitoba, CA., Crane HM; University of Washington, Seattle, WA, USA.
Jazyk:	angličtina
Zdroj:	Journal of acquired immune deficiency syndromes (1999) [J Acquir Immune Defic Syndr] 2023 Oct 01; Vol. 94 (2), pp. 135-142.
DOI:	10.1097/QAI.0000000000003242
Abstrakt:	Background: Tobacco smoking increases frailty risk among the general population and is common among people with HIV (PWH) who experience higher rates of frailty at younger ages than the general population. Methods: We identified 8608 PWH across 6 Centers for AIDS Research Network of Integrated Clinical Systems sites who completed ≥2 patient-reported outcome assessments, including a frailty phenotype measuring unintentional weight loss, poor mobility, fatigue, and inactivity, and scored 0-4. Smoking was measured as baseline pack-years and time-updated never, former, or current use with cigarettes/day. We used Cox models to associate smoking with risk of incident frailty (score ≥3) and deterioration (frailty score increase by ≥2 points), adjusted for demographics, antiretroviral medication, and time-updated CD4 count. Results: The mean follow-up of PWH was 5.3 years (median: 5.0), the mean age at baseline was 45 years, 15% were female, and 52% were non-White. At baseline, 60% reported current or former smoking. Current (HR: 1.79; 95% confidence interval: 1.54 to 2.08) and former (HR: 1.31; 95% confidence interval: 1.12 to 1.53) smoking were associated with higher incident frailty risk, as were higher pack-years. Current smoking (among younger PWH) and pack-years, but not former smoking, were associated with higher risk of deterioration. Conclusions: Among PWH, smoking status and duration are associated with incident and worsening frailty. Competing Interests: The authors have no conflicts of interest to disclose. (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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