BMI, insulin sensitivity, and cognition in early type 2 diabetes: The Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study.

Autor: Luchsinger JA; Departments of Medicine and Epidemiology, Columbia University Irving Medical Center, New York, New York, USA., Kazemi EJ; The Biostatistics Center, Department of Biostatistics and Bioinformatics, Milken Institute of Public Health, The George Washington University, Rockville, Maryland, USA., Sanchez DL; Department of Neurology, Gertrude H. Hergievsky Center, Columbia University Irving Medical Center, New York, New York, USA., Larkin ME; Massachusetts General Hospital Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA., Valencia WM; Department of Medicine, University of Miami, Miami, Florida, USA.; Geriatric Research Education and Clinical Center, Miami VA Healthcare System, Miami, Florida, USA.; Department of Humanities, Health and Society, Florida International University, Miami, Florida, USA., Desouza C; Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, Nebraska, USA., Carlson AL; International Diabetes Center, Minneapolis, Minnesota, USA., Pop-Busui R; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA., Seaquist ER; Department of Medicine, University of Minnesota, Minneapolis, Minneapolis, USA., Florez HJ; Department of Medicine, University of Miami, Miami, Florida, USA.; Geriatric Research Education and Clinical Center, Miami VA Healthcare System, Miami, Florida, USA.; Medical College of South Carolina, Charleston, South Carolina, USA., Barzilay J; Kaiser Permanente of Georgia, Duluth, Georgia, USA.
Jazyk: angličtina
Zdroj: Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2023 Jul; Vol. 31 (7), pp. 1812-1824.
DOI: 10.1002/oby.23785
Abstrakt: Objective: This study explored the association of BMI and insulin sensitivity with cognitive performance in type 2 diabetes.
Methods: A cross-sectional analysis of data from the baseline assessment of the Glycemia Reduction Approaches in Diabetes: a Comparative Effectiveness Study (GRADE) was conducted. BMI was used as a surrogate of adiposity and the Matsuda index as the measure of insulin sensitivity. Cognitive tests included the Spanish English Verbal Learning Test, the Digit Symbol Substitution Test, and the letter and animal fluency tests.
Results: Cognitive assessments were completed by 5018 (99.4%) of 5047 participants aged 56.7 ± 10.0 years, of whom 36.4% were female. Higher BMI and lower insulin sensitivity were related to better performance on memory and verbal fluency tests. In models including BMI and insulin sensitivity simultaneously, only higher BMI was related to better cognitive performance.
Conclusions: In this study, higher BMI and lower insulin sensitivity in type 2 diabetes were cross-sectionally associated with better cognitive performance. However, only higher BMI was related to cognitive performance when both BMI and insulin sensitivity were considered simultaneously. The causality and mechanisms for this association need to be determined in future studies.
(© 2023 The Obesity Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.)
Databáze: MEDLINE
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