Blood group A enhances SARS-CoV-2 infection.

Autor:	Wu SC; Department of Pathology, Joint Program in Transfusion Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Arthur CM; Department of Pathology, Joint Program in Transfusion Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Jan HM; Department of Pathology, Joint Program in Transfusion Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Garcia-Beltran WF; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA., Patel KR; Department of Pathology, Joint Program in Transfusion Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Rathgeber MF; Department of Pathology, Joint Program in Transfusion Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Verkerke HP; Department of Pathology, Joint Program in Transfusion Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA., Cheedarla N; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA., Jajosky RP; Department of Pathology, Joint Program in Transfusion Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Paul A; Department of Pathology, Joint Program in Transfusion Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Neish AS; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA., Roback JD; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA.; Center for Transfusion Medicine and Cellular Therapies, Emory University School of Medicine, Atlanta, GA., Josephson CD; Department of Hematology and Oncology, Johns Hopkins University All Children's Hospital, St. Petersburg, FL., Wesemann DR; Division of Allergy and Clinical Immunology and Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Kalman D; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA., Rakoff-Nahoum S; Division of Infectious Disease, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA., Cummings RD; National Center for Functional Glycomics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA., Stowell SR; Department of Pathology, Joint Program in Transfusion Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Jazyk:	angličtina
Zdroj:	Blood [Blood] 2023 Aug 24; Vol. 142 (8), pp. 742-747.
DOI:	10.1182/blood.2022018903
Abstrakt:	Among the risk factors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ABO(H) blood group antigens are among the most recognized predictors of infection. However, the mechanisms by which ABO(H) antigens influence susceptibility to COVID-19 remain incompletely understood. The receptor-binding domain (RBD) of SARS-CoV-2, which facilitates host cell engagement, bears significant similarity to galectins, an ancient family of carbohydrate-binding proteins. Because ABO(H) blood group antigens are carbohydrates, we compared the glycan-binding specificity of SARS-CoV-2 RBD with that of galectins. Similar to the binding profile of several galectins, the RBDs of SARS-CoV-2, including Delta and Omicron variants, exhibited specificity for blood group A. Not only did each RBD recognize blood group A in a glycan array format, but each SARS-CoV-2 virus also displayed a preferential ability to infect blood group A-expressing cells. Preincubation of blood group A cells with a blood group-binding galectin specifically inhibited the blood group A enhancement of SARS-CoV-2 infection, whereas similar incubation with a galectin that does not recognize blood group antigens failed to impact SARS-CoV-2 infection. These results demonstrated that SARS-CoV-2 can engage blood group A, providing a direct link between ABO(H) blood group expression and SARS-CoV-2 infection. (© 2023 by The American Society of Hematology.)
Databáze:	MEDLINE
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