Combined electric and magnetic field therapy for bone repair and regeneration: an investigation in a 3-mm and an augmented 17-mm tibia osteotomy model in sheep.

Autor: Darwiche SE; Musculoskeletal Research Unit (MSRU), University of Zürich, Winterthurerstrasse 260, 8057, Zürich, Switzerland. sdarwiche@vetclinics.uzh.ch.; Center for Applied Biotechnology and Molecular Medicine (CABMM), University of Zürich, Zürich, Switzerland. sdarwiche@vetclinics.uzh.ch., Kaczmarek A; Musculoskeletal Research Unit (MSRU), University of Zürich, Winterthurerstrasse 260, 8057, Zürich, Switzerland., Schwarzenberg P; Lehigh University, Bethlehem, PA, USA., Inglis BJ; Lehigh University, Bethlehem, PA, USA., Lechmann B; Johnson & Johnson Family of Companies, Solothurn, Switzerland., Kronen P; Musculoskeletal Research Unit (MSRU), University of Zürich, Winterthurerstrasse 260, 8057, Zürich, Switzerland.; Center for Applied Biotechnology and Molecular Medicine (CABMM), University of Zürich, Zürich, Switzerland., Ferguson SJ; Center for Applied Biotechnology and Molecular Medicine (CABMM), University of Zürich, Zürich, Switzerland.; Institute for Biomechanics, ETH Zürich, Zürich, Switzerland., Dailey H; Lehigh University, Bethlehem, PA, USA., von Rechenberg B; Musculoskeletal Research Unit (MSRU), University of Zürich, Winterthurerstrasse 260, 8057, Zürich, Switzerland.; Center for Applied Biotechnology and Molecular Medicine (CABMM), University of Zürich, Zürich, Switzerland., Klein K; Musculoskeletal Research Unit (MSRU), University of Zürich, Winterthurerstrasse 260, 8057, Zürich, Switzerland.
Jazyk: angličtina
Zdroj: Journal of orthopaedic surgery and research [J Orthop Surg Res] 2023 Jun 24; Vol. 18 (1), pp. 454. Date of Electronic Publication: 2023 Jun 24.
DOI: 10.1186/s13018-023-03910-6
Abstrakt: Background: Therapies using electromagnetic field technology show evidence of enhanced bone regeneration at the fracture site, potentially preventing delayed or nonunions.
Methods: Combined electric and magnetic field (CEMF) treatment was evaluated in two standardized sheep tibia osteotomy models: a 3-mm non-critical size gap model and a 17-mm critical size defect model augmented with autologous bone grafts, both stabilized with locking compression plates. CEMF treatment was delivered across the fracture gap twice daily for 90 min, starting 4 days postoperatively (post-OP) until sacrifice (9 or 12 weeks post-OP, respectively). Control groups received no CEMF treatment. Bone healing was evaluated radiographically, morphometrically (micro-CT), biomechanically and histologically.
Results: In the 3-mm gap model, the CEMF group (n = 6) exhibited higher callus mineral density compared to the Control group (n = 6), two-fold higher biomechanical torsional rigidity and a histologically more advanced callus maturity (no statistically significant differences). In the 17-mm graft model, differences between the Control (n = 6) and CEMF group (n = 6) were more pronounced. The CEMF group showed a radiologically more advanced callus, a higher callus volume (p = 0.003) and a 2.6 × higher biomechanical torsional rigidity (p = 0.024), combined with a histologically more advanced callus maturity and healing.
Conclusions: This study showed that CEMF therapy notably enhanced bone healing resulting in better new bone structure, callus morphology and superior biomechanical properties. This technology could transform a standard inert orthopedic implant into an active device stimulating bone tissue for accelerated healing and regeneration.
(© 2023. The Author(s).)
Databáze: MEDLINE
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