Valve disease in cardiac amyloidosis: an echocardiographic score.

Autor: Aimo A; Cardiology Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy. a.aimo@santannapisa.it.; Interdisciplinary Center for Health Sciences, Scuola Superiore Sant'Anna, Piazza Martiri della Libertà 33, 56124, Pisa, Italy. a.aimo@santannapisa.it., Fabiani I; Cardiology Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy., Maccarana A; Interdisciplinary Center for Health Sciences, Scuola Superiore Sant'Anna, Piazza Martiri della Libertà 33, 56124, Pisa, Italy., Vergaro G; Cardiology Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy.; Interdisciplinary Center for Health Sciences, Scuola Superiore Sant'Anna, Piazza Martiri della Libertà 33, 56124, Pisa, Italy., Chubuchny V; Cardiology Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy., Pasanisi EM; Cardiology Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy., Petersen C; Cardiology Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy., Poggianti E; Cardiology Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy., Giannoni A; Cardiology Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy.; Interdisciplinary Center for Health Sciences, Scuola Superiore Sant'Anna, Piazza Martiri della Libertà 33, 56124, Pisa, Italy., Spini V; Cardiology Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy., Taddei C; Cardiology Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy., Castiglione V; Interdisciplinary Center for Health Sciences, Scuola Superiore Sant'Anna, Piazza Martiri della Libertà 33, 56124, Pisa, Italy., Passino C; Cardiology Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy.; Interdisciplinary Center for Health Sciences, Scuola Superiore Sant'Anna, Piazza Martiri della Libertà 33, 56124, Pisa, Italy., Fontana M; National Amyloidosis Centre, University College London, Royal Free Campus, London, UK., Emdin M; Cardiology Division, Fondazione Toscana Gabriele Monasterio, Pisa, Italy.; Interdisciplinary Center for Health Sciences, Scuola Superiore Sant'Anna, Piazza Martiri della Libertà 33, 56124, Pisa, Italy., Venneri L; National Amyloidosis Centre, University College London, Royal Free Campus, London, UK.
Jazyk: angličtina
Zdroj: The international journal of cardiovascular imaging [Int J Cardiovasc Imaging] 2023 Oct; Vol. 39 (10), pp. 1873-1887. Date of Electronic Publication: 2023 Jun 21.
DOI: 10.1007/s10554-023-02901-2
Abstrakt: Cardiac amyloidosis (CA) may affect all cardiac structures, including the valves. From 423 patients undergoing a diagnostic workup for CA we selected 2 samples of 20 patients with amyloid transthyretin (ATTR-) or light-chain (AL-) CA, and age- and sex-matched controls. We chose 31 echocardiographic items related to the mitral, aortic and tricuspid valves, giving a value of 1 to each abnormal item. Patients with ATTR-CA displayed more often a shortened/hidden and restricted posterior mitral valve leaflet (PMVL), thickened mitral chordae tendineae and aortic stenosis than those with AL-CA, and less frequent PMVL calcification than matched controls. Score values were 15.8 (13.6-17.4) in ATTR-CA, 11.0 (9.3-14.9) in AL-CA, 12.8 (11.1-14.4) in ATTR-CA controls, and 11.0 (9.1-13.0) in AL-CA controls (p = 0.004 for ATTR- vs. AL-CA, 0.009 for ATTR-CA vs. their controls, and 0.461 for AL-CA vs. controls). Area under the curve values to diagnose ATTR-CA were 0.782 in patients with ATTR-CA or matched controls, and 0.773 in patients with LV hypertrophy. Patients with ATTR-CA have a prominent impairment of mitral valve structure and function, and higher score values. The valve score may help identify patients with ATTR-CA among patients with CA or unexplained hypertrophy.
(© 2023. The Author(s).)
Databáze: MEDLINE
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