Carboxylic acids that drive mosquito attraction to humans activate ionotropic receptors.

Autor: Ray G; Department of Biology, Baylor University, Waco, Texas, United States of America., Huff RM; Department of Biology, Baylor University, Waco, Texas, United States of America., Castillo JS; Department of Biological Sciences & Biomolecular Sciences Institute, Florida International University, Miami, Florida United States of America., Bellantuono AJ; Department of Biological Sciences & Biomolecular Sciences Institute, Florida International University, Miami, Florida United States of America., DeGennaro M; Department of Biological Sciences & Biomolecular Sciences Institute, Florida International University, Miami, Florida United States of America., Pitts RJ; Department of Biology, Baylor University, Waco, Texas, United States of America.
Jazyk: angličtina
Zdroj: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2023 Jun 20; Vol. 17 (6), pp. e0011402. Date of Electronic Publication: 2023 Jun 20 (Print Publication: 2023).
DOI: 10.1371/journal.pntd.0011402
Abstrakt: The mosquito, Aedes aegypti, is highly anthropophilic and transmits debilitating arboviruses within human populations and between humans and non-human primates. Female mosquitoes are attracted to sources of blood by responding to odor plumes that are emitted by their preferred hosts. Acidic volatile compounds, including carboxylic acids, represent particularly salient odors driving this attraction. Importantly, carboxylic acids are major constituents of human sweat and volatiles generated by skin microbes. As such, they are likely to impact human host preference, a dominant factor in disease transmission cycles. A more complete understanding of mosquito host attraction will necessitate the elucidation of molecular mechanisms of volatile odor detection that function in peripheral sensory neurons. Recent studies have shown that members of the variant ionotropic glutamate receptor gene family are necessary for physiological and behavioral responses to acidic volatiles in Aedes. In this study, we have identified a subfamily of variant ionotropic receptors that share sequence homology across several important vector species and are likely to be activated by carboxylic acids. Moreover, we demonstrate that selected members of this subfamily are activated by short-chain carboxylic acids in a heterologous cell expression system. Our results are consistent with the hypothesis that members of this receptor class underlie acidic volatile sensitivity in vector mosquitoes and provide a frame of reference for future development of novel mosquito attractant and repellent technologies.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Ray et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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