Multisystem inflammatory syndrome in children: an evolving understanding of a syndrome amid the inflammatory continuum.

Autor:	Areti S; Department of Medicine, Case Western University School of Medicine, University Hospitals of Cleveland, Cleveland, OH, USA.; Department of Pediatrics, Case Western University School of Medicine, Rainbow Babies and Children's Hospital, Cleveland, OH, USA., Parrillo M; Department of Pediatrics, Case Western University School of Medicine, Rainbow Babies and Children's Hospital, Cleveland, OH, USA., Baker L; Department of Pediatrics, Case Western University School of Medicine, Rainbow Babies and Children's Hospital, Cleveland, OH, USA., Meszaros A; Division of Basic Research, Washington University in St. Louis, Barnes-Jewish Hospital, St. Louis, MO, USA., Dram A; Division of Basic Research, Washington University in St. Louis, Barnes-Jewish Hospital, St. Louis, MO, USA., Remy KE; Department of Medicine, Case Western University School of Medicine, University Hospitals of Cleveland, Cleveland, OH, USA - kenneth.remy@uhhospitals.org.; Department of Pediatrics, Case Western University School of Medicine, Rainbow Babies and Children's Hospital, Cleveland, OH, USA.
Jazyk:	angličtina
Zdroj:	Minerva pediatrics [Minerva Pediatr (Torino)] 2024 Aug; Vol. 76 (4), pp. 545-555. Date of Electronic Publication: 2023 Jun 16.
DOI:	10.23736/S2724-5276.23.07279-8
Abstrakt:	Multisystem inflammatory syndrome in children (MIS-C) is a rare hyperinflammatory and immunosuppressed condition affecting children exposed to COVID-19. MIS-C has been associated with an over-exaggerated innate and adaptive immune response characterized by a 'selective' cytokine production and T cell suppression. As COVID-19 information has evolved, the knowledge and field surrounding MIS-C is ever evolving. Thus, a comprehensive clinical review that concisely presents current literature findings regarding common clinical presentations and comparisons with similar conditions, associations with the COVID-19 vaccine effects and relevant epigenetic markers and evaluates treatment and long-term outcomes to help guide future studies is needed and provided.
Databáze:	MEDLINE
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