Cochlear tonotopy from proteins to perception.

Autor: Fettiplace R; Department of Neuroscience, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Jazyk: angličtina
Zdroj: BioEssays : news and reviews in molecular, cellular and developmental biology [Bioessays] 2023 Aug; Vol. 45 (8), pp. e2300058. Date of Electronic Publication: 2023 Jun 17.
DOI: 10.1002/bies.202300058
Abstrakt: A ubiquitous feature of the auditory organ in amniotes is the longitudinal mapping of neuronal characteristic frequencies (CFs), which increase exponentially with distance along the organ. The exponential tonotopic map reflects variation in hair cell properties according to cochlear location and is thought to stem from concentration gradients in diffusible morphogenic proteins during embryonic development. While in all amniotes the spatial gradient is initiated by sonic hedgehog (SHH), released from the notochord and floorplate, subsequent molecular pathways are not fully understood. In chickens, BMP7 is one such morphogen, secreted from the distal end of the cochlea. In mammals, the developmental mechanism differs from birds and may depend on cochlear location. A consequence of exponential maps is that each octave occupies an equal distance on the cochlea, a spacing preserved in the tonotopic maps in higher auditory brain regions. This may facilitate frequency analysis and recognition of acoustic sequences.
(© 2023 The Authors. BioEssays published by Wiley Periodicals LLC.)
Databáze: MEDLINE
Externí odkaz: