Prognostic Impact of Poor Differentiation of Squamous Cell Carcinoma in Treatment Naïve Node-Negative Early Oral Cancers.

Autor: Mathur R; Department of Head and Neck Surgical Oncology, Tata Memorial Centre, Homi Bhabha Block, Tata Memorial Hospital, Parel, Homi Bhabha National Institute, 1209, Dr Ernest Borges Marg, Mumbai, 400012 India., Malik A; Department of Head and Neck Surgical Oncology, Tata Memorial Centre, Homi Bhabha Block, Tata Memorial Hospital, Parel, Homi Bhabha National Institute, 1209, Dr Ernest Borges Marg, Mumbai, 400012 India.; Department of Surgical Oncology, Max Institute of Cancer Care, Saket, New Delhi, 110017 India., Mishra A; Department of Head and Neck Surgical Oncology, Tata Memorial Centre, Homi Bhabha Block, Tata Memorial Hospital, Parel, Homi Bhabha National Institute, 1209, Dr Ernest Borges Marg, Mumbai, 400012 India., Mair M; Department of Head and Neck Surgical Oncology, Tata Memorial Centre, Homi Bhabha Block, Tata Memorial Hospital, Parel, Homi Bhabha National Institute, 1209, Dr Ernest Borges Marg, Mumbai, 400012 India., Singh AG; Department of Head and Neck Surgical Oncology, Tata Memorial Centre, Homi Bhabha Block, Tata Memorial Hospital, Parel, Homi Bhabha National Institute, 1209, Dr Ernest Borges Marg, Mumbai, 400012 India., Singhavi HR; Department of Head and Neck Surgical Oncology, Tata Memorial Centre, Homi Bhabha Block, Tata Memorial Hospital, Parel, Homi Bhabha National Institute, 1209, Dr Ernest Borges Marg, Mumbai, 400012 India., Mahuvakar AD; Department of Head and Neck Surgical Oncology, Tata Memorial Centre, Homi Bhabha Block, Tata Memorial Hospital, Parel, Homi Bhabha National Institute, 1209, Dr Ernest Borges Marg, Mumbai, 400012 India., Qayuumi B; Department of Head and Neck Surgical Oncology, Tata Memorial Centre, Homi Bhabha Block, Tata Memorial Hospital, Parel, Homi Bhabha National Institute, 1209, Dr Ernest Borges Marg, Mumbai, 400012 India., Shetty KSR; Department of Head and Neck Surgical Oncology, Tata Memorial Centre, Homi Bhabha Block, Tata Memorial Hospital, Parel, Homi Bhabha National Institute, 1209, Dr Ernest Borges Marg, Mumbai, 400012 India., Bal M; Department of Pathology, Tata Memorial Centre, Parel, Homi Bhabha National Institute, Mumbai, 400012 India., Nair SV; Department of Head and Neck Surgical Oncology, Tata Memorial Centre, Homi Bhabha Block, Tata Memorial Hospital, Parel, Homi Bhabha National Institute, 1209, Dr Ernest Borges Marg, Mumbai, 400012 India., Nair D; Department of Head and Neck Surgical Oncology, Tata Memorial Centre, Homi Bhabha Block, Tata Memorial Hospital, Parel, Homi Bhabha National Institute, 1209, Dr Ernest Borges Marg, Mumbai, 400012 India., Chaturvedi P; Department of Head and Neck Surgical Oncology, Tata Memorial Centre, Homi Bhabha Block, Tata Memorial Hospital, Parel, Homi Bhabha National Institute, 1209, Dr Ernest Borges Marg, Mumbai, 400012 India.
Jazyk: angličtina
Zdroj: Indian journal of surgical oncology [Indian J Surg Oncol] 2023 Jun; Vol. 14 (2), pp. 524-530. Date of Electronic Publication: 2023 Feb 13.
DOI: 10.1007/s13193-023-01712-0
Abstrakt: We have conducted this study to understand the impact of poor differentiation (PD), as a sole poor prognostic factor, in early oral cancers. This was a retrospective analysis of a prospectively maintained database of clinically node-negative early T stage OSCC patients operated between 2012 and 2014. Impact of PD on the survival and role of adjuvant therapy in these patients was noted. Out of 1172 patients screened, 280 patients were found to be eligible for the study. 11.4% patients had PDSCC. It was found to be associated with tongue cancers and peri-neural invasion. It had a significant impact on OS and DFS (48.7 months vs 81.4 months, p < 0.00 and 44.6 months vs 73.5 months, p < 0.00 respectively. Hazard ratio for DFS: 4.08. Although patients with PDSCC had better survival with radiotherapy, but this was not statistically significant. Poor differentiation as a stand-alone factor impacts survival in patients with early oral cancer. It may be seen more often in patients with tongue cancer and may have associated PNI. The role of adjuvant therapy in such patients is not clear.
Competing Interests: Conflict of InterestThe authors declare no competing interests.
(© The Author(s), under exclusive licence to Indian Association of Surgical Oncology 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
Databáze: MEDLINE
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