The local skin cellular immune response determines the clinical outcome of sarcoptic mange in Iberian ibex ( Capra pyrenaica ).

Autor:	Valldeperes M; Wildlife Ecology and Health Group (WE&H), Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.; Departament de Medicina i Cirurgia Animals, Servei d'Ecopatologia de Fauna Salvatge (SEFaS), Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Granados JE; Wildlife Ecology and Health Group (WE&H), Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.; Parque Nacional y Parque Natural de Sierra Nevada, Granada, Spain., Pérez V; Department of Animal Health-Instituto de Ganadería de Montaña (IGM), ULe-CSIC León, León, Spain.; Faculty of Veterinary Science, University of León, León, Spain., López-Olvera JR; Wildlife Ecology and Health Group (WE&H), Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.; Departament de Medicina i Cirurgia Animals, Servei d'Ecopatologia de Fauna Salvatge (SEFaS), Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Ráez-Bravo A; Wildlife Ecology and Health Group (WE&H), Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.; Departament de Medicina i Cirurgia Animals, Servei d'Ecopatologia de Fauna Salvatge (SEFaS), Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Fandos P; Retired Researcher, Madrid, Spain., Pérez JM; Wildlife Ecology and Health Group (WE&H), Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.; Department of Animal and Plant Biology, and Ecology, Jaén University, Campus Las Lagunillas, Jaén, Spain., Mentaberre G; Wildlife Ecology and Health Group (WE&H), Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.; Departament de Ciència Animal, Universitat de Lleida (UdL), Lleida, Spain., Tampach S; Wildlife Ecology and Health Group (WE&H), Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.; Departament de Medicina i Cirurgia Animals, Servei d'Ecopatologia de Fauna Salvatge (SEFaS), Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Soriguer RC; Estación Biológica de Doñana (CSIC), Sevilla, Spain., Espinosa J; Department of Animal Health-Instituto de Ganadería de Montaña (IGM), ULe-CSIC León, León, Spain.; Faculty of Veterinary Science, University of León, León, Spain.
Jazyk:	angličtina
Zdroj:	Frontiers in veterinary science [Front Vet Sci] 2023 Jun 01; Vol. 10, pp. 1183304. Date of Electronic Publication: 2023 Jun 01 (Print Publication: 2023).
DOI:	10.3389/fvets.2023.1183304
Abstrakt:	Introduction: Sarcoptic mange, caused by Sarcoptes scabiei , is a disease with implications for wildlife conservation and management. Its severity depends on the host's local skin immune response, which is largely unknown in Iberian ibex ( Capra pyrenaica ), a mountain ungulate dramatically affected by mange. In this species, the clinical outcome of sarcoptic mange varies among individuals, and the local immune response could be key to controlling the infestation. This study aims to characterize the local cellular immune response and its relationship with the clinical outcome. Methods: Fourteen Iberian ibexes were experimentally infested with S. scabiei and six more served as controls. Clinical signs were monitored, and skin biopsies were collected from the withers at 26, 46, and 103 days post-infection (dpi). The presence and distribution of macrophages (including M1 and M2 phenotypes), T lymphocytes, B lymphocytes, plasma cells, and interleukine 10 were quantitatively evaluated using immunohistochemical techniques. Results: An inflammatory infiltrate that decreased significantly from 26 to 103 dpi was observed in all the infested ibexes. The predominant inflammatory cell population in the skin of the mangy ibexes was formed by macrophages (mainly the M2 phenotype) followed by T lymphocytes, with lower numbers of B lymphocytes and plasma cells. Three clinical courses were identified: total recovery, partial recovery, and terminal stage. The inflammatory infiltrates were less pronounced in the fully recovered ibexes than in those that progressed to the terminal stage throughout the study. Discussion: The results suggest an exacerbated but effective Th1-type cellular immune response controlling mange in Iberian ibex. Furthermore, the local immune response appears to determine the variability of the clinical responses to S. scabiei infestation in this species. This first report on the progression of local skin immune cells is relevant not only for individuals but also for population management and conservation. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Valldeperes, Granados, Pérez, López-Olvera, Ráez-Bravo, Fandos, Pérez, Mentaberre, Tampach, Soriguer and Espinosa.)
Databáze:	MEDLINE
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