Guava-fruit based synthesis of carbon quantum dots for spectrofluorometric quantitative analysis of risperidone in spiked human plasma and pharmaceutical dosage forms.

Autor:	Alaqel SI; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Northern Border University Rafha 91911 Saudi Arabia., Abdullah O; Pharmaceutical Chemistry Department, College of Pharmacy, Umm Al-Qura University Makkah Saudi Arabia., Alharbi A; Clinical Pharmacy Department, College of Pharmacy, Umm Al-Qura University Makkah Saudi Arabia assharbi@uqu.edu.sa., Althobaiti YS; Addiction and Neuroscience Research Unit, Health Science Campus, Taif University P.O. Box 11099 Taif 21944 Saudi Arabia.; Department of Pharmacology and Toxicology, Taif University P.O. Box 11099 Taif 21944 Saudi Arabia., Alturki MS; Department of Pharmaceutical Chemistry, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University 34212 Dammam Saudi Arabia., Ramzy S; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University 11751 Nasr City Cairo Egypt ssherif14@azhar.edu.eg., Almalki AH; Addiction and Neuroscience Research Unit, Health Science Campus, Taif University P.O. Box 11099 Taif 21944 Saudi Arabia.; Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University P.O. Box 11099 Taif 21944 Saudi Arabia.
Jazyk:	angličtina
Zdroj:	RSC advances [RSC Adv] 2023 Jun 13; Vol. 13 (26), pp. 17765-17774. Date of Electronic Publication: 2023 Jun 13 (Print Publication: 2023).
DOI:	10.1039/d3ra02855k
Abstrakt:	Autism is one of the most pressing issues facing the international community in recent years, particularly in Middle Eastern countries. Risperidone is a selective serotonin type 2 and dopamine type 2 receptor antagonist. It is the most administered antipsychotic medication in children with autism-related behavioral disorders. Therapeutic monitoring of risperidone may improve safety and efficacy in autistic individuals. The main objective of this work was to develop a highly sensitive green fitted method for the determination of risperidone in the plasma matrix and pharmaceutical dosage forms. Novel water-soluble N-carbon quantum dots were synthesized from guava fruit, a natural green precursor, and used for determination of risperidone based on quenching fluorescence spectroscopy phenomena. The synthesized dots were characterized by transmission electron microscopy and Fourier transform infrared spectroscopy. The synthesized N-carbon quantum dots exhibited aquantum yield of 26.12% and showed a strong emission fluorescence peak at 475 nm when excited at 380 nm. The fluorescence intensity of the N-carbon quantum dots decreased with increasing risperidone concentration, indicating that the fluorescence quenching was concentration dependent. The presented method was carefully optimized and validated according to the guidelines of ICH, and it demonstrated good linearity in a concentration range of 5-150 ng mL -1 . With a LOD of 1.379 ng mL -1 and a LOQ of 4.108 ng mL -1 , the technique was extremely sensitive. Due to the high sensitivity of the proposed method, it could be effectively used for the determination of risperidone in the plasma matrix. The proposed method was compared with the previously reported HPLC method in terms of sensitivity and green chemistry metrics. The proposed method proved to be more sensitive and compatible with the principles of green analytical chemistry. Competing Interests: There are no conflicts to declare. (This journal is © The Royal Society of Chemistry.)
Databáze:	MEDLINE
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