NK cells direct the perspective approaches to cancer immunotherapy.

Autor: Jalil AT; Department of Medical Laboratories Techniques, Al-Mustaqbal University College, Hilla, Babylon, Iraq. abedalazeem799@gmail.com., Abdulhadi MA; Department of Medical Laboratory Techniques, Al-Maarif University College, Al-Anbar, Iraq., Al-Marzook FA; College of Medical and Health Technologies, Al-Zahraa University for Women, Karbala, 56100, Iraq., Hizam MM; National University of Science and Technology, Nasiriyah, Dhi Qar, Iraq., Abdulameer SJ; Biology Department, College of Education for Pure Science, Wasit University, Kut, Wasit, Iraq., Al-Azzawi AKJ; Dentistry Department, Al-Turath University College, Baghdad, Iraq., Zabibah RS; Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq., Fadhil AA; Medical Technical College, Al-Farahidi University, Baghdad, Iraq.
Jazyk: angličtina
Zdroj: Medical oncology (Northwood, London, England) [Med Oncol] 2023 Jun 15; Vol. 40 (7), pp. 206. Date of Electronic Publication: 2023 Jun 15.
DOI: 10.1007/s12032-023-02066-x
Abstrakt: Natural killer (NK) cells are innate immune cells with cytotoxic potentials to kill cancerous cells in several mechanisms, which could be implied for cancer therapy. While potent, their antitumor activities specially for solid tumors impaired by inadequate tumor infiltration, suppressive tumor microenvironment, cancer-associated stroma cells, and tumor-supportive immune cells. Therefore, manipulating or reprogramming these barriers by prospective strategies might improve current immunotherapies in the clinic or introduce novel NK-based immunotherapies. NK-based immunotherapy could be developed in monotherapy or in combination with other therapeutic regimens such as oncolytic virus therapy and immune checkpoint blockade, as presented in this review.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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