Insights into the relationship between persistent antibody secretion and metabolic programming - A question for single-cell analysis.

Autor: Bucheli OTM; Laboratory for Functional Immune Repertoire Analysis, Institute of Pharmaceutical Sciences, D-CHAB, ETH Zürich, 8093 Zürich, Switzerland., Eyer K; Laboratory for Functional Immune Repertoire Analysis, Institute of Pharmaceutical Sciences, D-CHAB, ETH Zürich, 8093 Zürich, Switzerland. Electronic address: klaus.eyer@pharma.ethz.ch.
Jazyk: angličtina
Zdroj: Immunology letters [Immunol Lett] 2023 Aug; Vol. 260, pp. 35-43. Date of Electronic Publication: 2023 Jun 12.
DOI: 10.1016/j.imlet.2023.06.006
Abstrakt: Vaccination aims to generate a protective and persisting antibody response. Indeed, humoral vaccine-mediated protection depends on the quality and quantity of the produced antigen-specific antibodies for its initial magnitude and the persistence of the plasma cells for its duration. Therefore, understanding the mechanisms behind the generation, selection and maintenance of long-lived plasma cells secreting protective antibodies is of fundamental importance for understanding long-term immunity, vaccine responses, therapeutical approaches for autoimmune disease and multiple myeloma. Recent studies have observed correlations between the generation, function and lifespan of plasma cells and their metabolism, with metabolism being both a main driver and primary consequence of changes in cellular behavior. This review introduces how metabolic programs influence and drive immune cell functions in general and plasma cell differentiation and longevity more specifically, summarizing the current knowledge on metabolic pathways and their influences on cellular fate. In addition, available technologies to profile metabolism and their limitations are discussed, leading to the unique and open technological challenges for further advancement of this research field.
Competing Interests: Declaration of Competing Interest E.K. holds several patents on single-cell analysis and is the co-founder of a start-up developing instruments for functional and direct single-cell analysis. O.T.M.B. has no conflict of interest to declare.
(Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: