Fungal siderophore metabolism with a focus on Aspergillus fumigatus: impact on biotic interactions and potential translational applications.
| Autor: | Happacher I; Institute of Molecular Biology, Biocenter, Medical University of Innsbruck, 6020 Innsbruck, Austria., Aguiar M; Institute of Molecular Biology, Biocenter, Medical University of Innsbruck, 6020 Innsbruck, Austria., Yap A; Institute of Molecular Biology, Biocenter, Medical University of Innsbruck, 6020 Innsbruck, Austria., Decristoforo C; Department of Nuclear Medicine, Medical University Innsbruck, Innsbruck, Austria., Haas H; Institute of Molecular Biology, Biocenter, Medical University of Innsbruck, 6020 Innsbruck, Austria. |
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| Jazyk: | angličtina |
| Zdroj: | Essays in biochemistry [Essays Biochem] 2023 Sep 13; Vol. 67 (5), pp. 829-842. |
| DOI: | 10.1042/EBC20220252 |
| Abstrakt: | Iron is an essential trace element that is limiting in most habitats including hosts for fungal pathogens. Siderophores are iron-chelators synthesized by most fungal species for high-affinity uptake and intracellular handling of iron. Moreover, virtually all fungal species including those lacking siderophore biosynthesis appear to be able to utilize siderophores produced by other species. Siderophore biosynthesis has been shown to be crucial for virulence of several fungal pathogens infecting animals and plants revealing induction of this iron acquisition system during virulence, which offers translational potential of this fungal-specific system. The present article summarizes the current knowledge on the fungal siderophore system with a focus on Aspergillus fumigatus and its potential translational application including noninvasive diagnosis of fungal infections via urine samples, imaging of fungal infections via labeling of siderophores with radionuclides such as Gallium-68 for detection with positron emission tomography, conjugation of siderophores with fluorescent probes, and development of novel antifungal strategies. (© 2023 The Author(s).) |
| Databáze: | MEDLINE |
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