Efficacy and safety of EGFR inhibitor gefitinib in recurrent or metastatic cervical cancer: a preliminary report.

Autor: Krishna A; Department of Radiation Oncology, Kasturba Medical College, Mangalore, India. abhishek.krishna@manipal.edu., Sathya M; Department of Radiation Oncology, Mysore Medical College and Research Institute, Mysore, India., Mukesh S; Department of Radiation Oncology, Mysore Medical College and Research Institute, Mysore, India., Athiyamaan MS; Department of Radiation Oncology, Kasturba Medical College, Mangalore, India., Banerjee S; Department of Radiation Oncology, Kasturba Medical College, Mangalore, India., Sunny J; Department of Radiation Oncology, Kasturba Medical College, Mangalore, India., Srinivas C; Department of Radiation Oncology, Kasturba Medical College, Mangalore, India., Lobo D; Department of Radiation Oncology, Kasturba Medical College, Mangalore, India., Makkapatti BS; Department of Radiation Oncology, Kasturba Medical College, Mangalore, India., Jawahar V; Department of Radiation Oncology, Kasturba Medical College, Mangalore, India.
Jazyk: angličtina
Zdroj: Medical oncology (Northwood, London, England) [Med Oncol] 2023 Jun 13; Vol. 40 (7), pp. 203. Date of Electronic Publication: 2023 Jun 13.
DOI: 10.1007/s12032-023-02070-1
Abstrakt: There has been growing interest in the use of epidermal growth factor receptor inhibitors in various cancers. The study was conducted to evaluate the efficacy and safety of gefitinib as a monotherapy in patients with recurrent or metastatic cervical cancer. Patients with cervical carcinoma who experienced locoregional recurrence or distant metastases either at presentation or after definitive combined chemoradiotherapy or postoperative radiotherapy were enrolled. Gefitinib was administered orally at a dose of 250 mg/d to eligible patients. Treatment with Gefitinib was continued until disease progression, intolerable adverse effects were developed, or consent was withdrawn. Clinical and radiological investigations were used to verify the disease response. Toxicity was graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0. The study enrolled 32 patients who met the eligibility criteria. Thirty patients were available for the analysis. The majority of the patients included in the analysis had FIGO stage IIIB disease at their initial presentation. The median follow-up time was 6 months (3-15 months). Two patients (7%) had a complete clinical response, 7 patients (23%) had a partial response, 5 patients (17%) showed a stable disease and 16 patients had progressive disease (53%). The disease control rate was 47%. The median PFS was noted to be 4.5 months and the 1-year PFS was 20%. None of the individuals experienced toxicity of grade 3 or higher. All toxicities were managed conservatively. The study suggests that gefitinib may be a promising therapeutic option for patients with advanced cervical cancer who have limited treatment alternatives.
(© 2023. The Author(s).)
Databáze: MEDLINE
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